GATA2 anticorps (N-Term)

N° du produit ABIN2777458

Détail du produit anti-GATA2 anticorps

Antigène: GATA2 (GATA Binding Protein 2 (GATA2))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Lapin, Boeuf (Vache), Chien, Cobaye, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GATA2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: PYYANPAHAR ARVSYSPAHA RLTGGQMCRP HLLHSPGLPW LDGGKAALSA

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against GATA2. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human GATA2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 480 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-GATA2 (ABIN2777458)

Wang, Zhu, Guo, Dong, Liu, Yin, Zhang, Li, Liu, Ma, Song, He, Wang, Wang, Zhang, Li, Yu: "A regulatory circuit comprising GATA1/2 switch and microRNA-27a/24 promotes erythropoiesis." dans: Nucleic acids research, Vol. 42, Issue 1, pp. 442-57, (2013) (PubMed).

Fujiwara, Yokoyama, Okitsu, Kamata, Fukuhara, Onishi, Fujimaki, Takahashi, Ishizawa, Bresnick, Harigae: "Gene expression profiling identifies HOXB4 as a direct downstream target of GATA-2 in human CD34+ hematopoietic cells." dans: PLoS ONE, Vol. 7, Issue 9, pp. e40959, (2012) (PubMed).

Jack, Crossley: "GATA proteins work together with friend of GATA (FOG) and C-terminal binding protein (CTBP) co-regulators to control adipogenesis." dans: The Journal of biological chemistry, Vol. 285, Issue 42, pp. 32405-14, (2010) (PubMed).

Huang, Niu, Liu, Wang, Sturgis, Wei: "The functional IGFBP7 promoter -418G>A polymorphism and risk of head and neck cancer." dans: Mutation research, Vol. 702, Issue 1, pp. 32-9, (2010) (PubMed).

Mammoto, Connor, Mammoto, Yung, Huh, Aderman, Mostoslavsky, Smith, Ingber: "A mechanosensitive transcriptional mechanism that controls angiogenesis." dans: Nature, Vol. 457, Issue 7233, pp. 1103-8, (2009) (PubMed).

Tsuzuki, Kitajima, Nakano, Glasow, Zelent, Enver: "Cross talk between retinoic acid signaling and transcription factor GATA-2." dans: Molecular and cellular biology, Vol. 24, Issue 15, pp. 6824-36, (2004) (PubMed).

Détails sur GATA2

Antigène: GATA2 (GATA Binding Protein 2 (GATA2))

Autre désignation: GATA2 (GATA2 Produits)

Sujet: The GATA family of transcription factors, which contain zinc fingers in their DNA binding domain, have emerged as candidate regulators of gene expression in hematopoietic cells is essential for normal primitive and definitive erythropoiesis and is expressed at high levels in erythroid cells, mast cells, and megakaryocytes. GATA2 is expressed in hematopoietic progenitors, including early erythroid cells, mast cells, and megakaryocytes, and also in nonhematopoietic embryonic stem cells.
Alias Symbols: DCML, NFE1B, MONOMAC
Protein Interaction Partner: NOTCH2NL, KRTAP10-3, KRTAP10-9, KRT40, PRR20A, ADAMTSL4, TRAF1, PSMA3, MDFI, GOLGA2, FHL3, TRIM23, AKT1, BMI1, SPI1, SMAD4, ELAVL1, KAT2A, EP300, MED1, POU1F1, POU2AF1, ZBTB32, ZFPM1, ZBTB16, HDAC5, HDAC3, HHEX, RARA, RXRA, MAPK1, JUN, CEBPA, STAT3, PML,
Protein Size: 480

Poids moléculaire: 50 kDa

ID gène: 2624

NCBI Accession: NM_032638, NP_116027

UniProt: P23769

Pathways: Stem Cell Maintenance