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NKX6-1 anticorps (N-Term)

NKX6-1 Reactivité: Humain, Souris, Rat, Chien, Cheval, Porc, Lapin, Boeuf (Vache), Poisson zèbre (Danio rerio) WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2777547
  • Antigène Voir toutes NKX6-1 Anticorps
    NKX6-1 (NK6 Homeobox 1 (NKX6-1))
    Épitope
    • 10
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 44
    • 23
    • 11
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Chien, Cheval, Porc, Lapin, Boeuf (Vache), Poisson zèbre (Danio rerio)
    Hôte
    • 36
    • 7
    • 1
    • 1
    Lapin
    Clonalité
    • 38
    • 7
    Polyclonal
    Conjugué
    • 26
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp NKX6-1 est non-conjugé
    Application
    • 34
    • 24
    • 7
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Séquence
    MLAVGAMEGT RQSAFLLSSP PLAALHSMAE MKTPLYPAAY PPLPAGPPSS
    Homologie
    Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%
    Attributs du produit
    This is a rabbit polyclonal antibody against NKX6-1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the N terminal region of human NKX6-1
    Top Product
    Discover our top product NKX6-1 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 367 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    NKX6-1 (NK6 Homeobox 1 (NKX6-1))
    Autre désignation
    NKX6-1 (NKX6-1 Produits)
    Synonymes
    anticorps nkx6a, anticorps nkx6.1, anticorps NKX6.1, anticorps NKX6A, anticorps zgc:92879, anticorps Nkx6.1, anticorps Nkx61, anticorps Nkx6a, anticorps NK6 homeobox 1, anticorps NK6 homeobox 1 L homeolog, anticorps nkx6-1, anticorps NKX6-1, anticorps nkx6.1, anticorps nkx6-1.L, anticorps Nkx6-1
    Sujet
    NKX6-1 is the transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. NKX6-1 is involved in transcriptional regulation in islet beta cells. Binds to the insulin promoter and is involved in regulation of the insulin gene. Together with NKX2-2 and IRX3, NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. NKX6-1 belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals.In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) [PubMed 15056733].[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-300 U66797.1 1-300 301-307 AC096766.3 119394-119400 c 308-676 U66797.1 308-676 677-849 U66798.1 7-179 850-1116 U66799.1 7-273
    Alias Symbols: NKX6.1, NKX6A
    Protein Size: 367
    Poids moléculaire
    38 kDa
    ID gène
    4825
    NCBI Accession
    NM_006168, NP_006159
    UniProt
    P78426
    Pathways
    Dopaminergic Neurogenesis, Positive Regulation of Peptide Hormone Secretion
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