PPARG anticorps (N-Term)
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- Antigène Voir toutes PPARG Anticorps
- PPARG (Peroxisome Proliferator-Activated Receptor gamma (PPARG))
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Épitope
- N-Term
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Reactivité
- Humain, Chien, Porc
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp PPARG est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- MGETLGDSPI DPESDSFTDT LSANISQEMT MVDTEMPFWP TNFGISSVDL
- Homologie
- Dog: 92%, Human: 100%, Pig: 85%
- Attributs du produit
- This is a rabbit polyclonal antibody against PPARG. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the N terminal region of human PPARG
- Top Product
- Discover our top product PPARG Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 505 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- PPARG (Peroxisome Proliferator-Activated Receptor gamma (PPARG))
- Autre désignation
- PPARG (PPARG Produits)
- Synonymes
- anticorps PPAR gamma, anticorps PPARg2, anticorps PPARG, anticorps Nr1c3, anticorps PPAR-gamma, anticorps PPAR-gamma2, anticorps PPARgamma, anticorps PPARgamma2, anticorps NR1C3, anticorps CIMT1, anticorps GLM1, anticorps PPARG1, anticorps PPARG2, anticorps xPPAR-gamma, anticorps PPAR-GAMMA, anticorps PPARGAMMA, anticorps peroxisome proliferator-activated receptor gamma, anticorps peroxisome proliferator activated receptor gamma, anticorps peroxisome proliferator activated receptor gamma L homeolog, anticorps PPARG, anticorps Pparg, anticorps pparg.L
- Sujet
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PPARG is a receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. PPARG is the key regulator of adipocyte differentiation and glucose homeostasis.This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described.
Alias Symbols: NR1C3, PPARG1, PPARG2, GLM1, CIMT1, PPARgamma
Protein Interaction Partner: HDAC3, NCOA1, NCOA3, SUMO1, UBC, SUMO2, RXRA, MED1, HMGA1, EP300, NCOA2, CDC34, PRKAA2, PRKAA1, PPARGC1A, ASH2L, RBBP5, NSD1, NCOA6, PAXIP1, MUC1, NR3C1, SMAD2, CREBBP, ALOX15B, ZFYVE9, USP7, NCOR1, CDK5, SMARCD3, SMARCA4, NEDD4, BCAS2, MIF4GD, MED14, JAZ
Protein Size: 505 - Poids moléculaire
- 57 kDa
- ID gène
- 5468
- NCBI Accession
- NM_015869, NP_056953
- UniProt
- P37231
- Pathways
- Signalisation MAPK, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Endopeptidase Activity, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation
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