KDM4C anticorps (C-Term)

N° du produit ABIN2777688

Détail du produit anti-KDM4C anticorps

Antigène: KDM4C (Lysine (K)-Specific Demethylase 4C (KDM4C))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Lapin, Boeuf (Vache), Chien, Cheval, Porc, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KDM4C est non-conjugé

Application: Western Blotting (WB)

Séquence: CLCNLRGGAL KQTKNNKWAH VMCAVAVPEV RFTNVPERTQ IDVGRIPLQR

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against JMJD2C. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human JMJD2C

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 813 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-KDM4C (ABIN2777688)

Lu, Ward, Kapoor, Rohle, Turcan, Abdel-Wahab, Edwards, Khanin, Figueroa, Melnick, Wellen, ORourke, Berger, Chan, Levine, Mellinghoff, Thompson: "IDH mutation impairs histone demethylation and results in a block to cell differentiation." dans: Nature, Vol. 483, Issue 7390, pp. 474-8, (2012) (PubMed).

Détails sur KDM4C

Antigène: KDM4C (Lysine (K)-Specific Demethylase 4C (KDM4C))

Autre désignation: JMJD2C (KDM4C Produits)

Synonymes: anticorps JMJD2C, anticorps GASC1, anticorps JHDM3C, anticorps TDRD14C, anticorps bA146B14.1, anticorps 2410141F18Rik, anticorps AA517467, anticorps Gasc1, anticorps Jmjd2c, anticorps lysine demethylase 4C, anticorps jumonji domain containing 2c, anticorps lysine (K)-specific demethylase 4C, anticorps KDM4C, anticorps Jmjd2c, anticorps kdm4c, anticorps Kdm4c

Sujet: JMJD2C is a member of the Jumonji domain 2 (JMJD2) family. It contains one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma.
Alias Symbols: FLJ25949, GASC1, JHDM3C, JMJD2C, KIAA0780, bA146B14.1
Protein Interaction Partner: UBC, HIST2H3C, HDAC3, PPARG, HDAC1, H3F3A, HIST1H3A, KDM4C, KDM4A,
Protein Size: 813

Poids moléculaire: 92 kDa

ID gène: 23081

NCBI Accession: NM_001146695, NP_001140167

UniProt: F5H347

Pathways: Nuclear Hormone Receptor Binding, L'effet Warburg