PRDM16 anticorps (Middle Region)

N° du produit ABIN2777828

Détail du produit anti-PRDM16 anticorps

Antigène: PRDM16 (PR Domain Containing 16 (PRDM16))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Chien, Cobaye, Cheval, Boeuf (Vache), Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRDM16 est non-conjugé

Application: Western Blotting (WB)

Séquence: LNHTQDAKLP SPLGNPALPL VSAVSNSSQG TTAAAGPEEK FESRLEDSCV

Homologie: Cow: 92%, Dog: 77%, Guinea Pig: 86%, Horse: 85%, Human: 100%, Mouse: 79%, Pig: 92%, Rat: 86%

Attributs du produit: This is a rabbit polyclonal antibody against PRDM16. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human PRDM16

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1275 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur PRDM16

Antigène: PRDM16 (PR Domain Containing 16 (PRDM16))

Autre désignation: PRDM16 (PRDM16 Produits)

Synonymes: anticorps PRDM16, anticorps wu:fc09g08, anticorps MEL1, anticorps PFM13, anticorps 5730557K01Rik, anticorps C130091E20, anticorps csp1, anticorps mKIAA1675, anticorps mel1, anticorps PR/SET domain 16, anticorps PR domain containing 16, anticorps PRDM16, anticorps prdm16, anticorps Prdm16

Sujet: The reciprocal translocation t(1,3)(p36,q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Alias Symbols: KIAA1675, MEL1, PFM13
Protein Interaction Partner: TFAP4, UBC, HDAC2, Ctbp2, SUMO1, SKI, SMAD3, SMAD2, INADL,
Protein Size: 1275

Poids moléculaire: 140 kDa

ID gène: 63976

NCBI Accession: NM_022114, NP_071397

UniProt: Q9HAZ2

Pathways: Stem Cell Maintenance, Brown Fat Cell Differentiation