SOX10 anticorps (Middle Region)

N° du produit ABIN2777864

Détail du produit anti-SOX10 anticorps

Antigène: SOX10 (SRY (Sex Determining Region Y)-Box 10 (SOX10))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SOX10 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: PGGEAEQGGT AAIQAHYKSA HLDHRHPGEG SPMSDGNPEH PSGQSHGPPT

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 86%

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human SOX10

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 466 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-SOX10 (ABIN2777864)

Wilson, Olm-Shipman, Acevedo, Palaniyandi, Hall, Kosa, Stumpff, Smith, Pitstick, Liao, Bjork, Czirok, Saadi: "SPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delamination." dans: Scientific reports, Vol. 6, pp. 17735, (2016) (PubMed).

Détails sur SOX10

Antigène: SOX10 (SRY (Sex Determining Region Y)-Box 10 (SOX10))

Autre désignation: SOX10 (SOX10 Produits)

Synonymes: anticorps DOM, anticorps PCWH, anticorps WS2E, anticorps WS4, anticorps WS4C, anticorps SOX-10, anticorps SOX10, anticorps dom, anticorps ws4, anticorps Dom, anticorps Sox21, anticorps SOX9, anticorps cls/sox10, anticorps zgc:100757, anticorps SRY-box 10, anticorps SRY box 10, anticorps SRY-box 10 L homeolog, anticorps SRY (sex determining region Y)-box 10, anticorps SOX10, anticorps Sox10, anticorps sox10.L, anticorps sox10

Sujet: SOX10 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. This protein may act as a transcriptional activator after forming a protein complex with other proteins. It acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease.
Alias Symbols: DOM, MGC15649, WS2E, WS4, PCWH, WS4C
Protein Interaction Partner: UBC, CDK6, EXOC5, NMI, EPAS1, POU3F2, UTF1, PAX3, UBE2I, OLIG2, HHEX, PAX6, ALX4, PRRX2, SUMO2, POU3F3, SUMO3, SOX10, SUMO1, TCF12, MEOX1, DLX5, HIVEP1, SP1, PRRX1, JUN, POU5F1, HOXC4, HOXA3, EGR2, CEBPA,
Protein Size: 466

Poids moléculaire: 50 kDa

ID gène: 6663

NCBI Accession: NM_006941, NP_008872

UniProt: P56693

Pathways: Chromatin Binding