ING3 anticorps (Middle Region)

N° du produit ABIN2777878

Détail du produit anti-ING3 anticorps

Antigène: ING3 (Inhibitor of Growth Family, Member 3 (ING3))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Cheval, Lapin, Poisson zèbre (Danio rerio), Saccharomyces cerevisiae

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ING3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: LSSGTGAGAI TMAAAQAVQA TAQMKEGRRT SSLKASYEAF KNNDFQLGKE

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 75%, Zebrafish: 92%

Attributs du produit: This is a rabbit polyclonal antibody against ING3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human ING3

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 418 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur ING3

Antigène: ING3 (Inhibitor of Growth Family, Member 3 (ING3))

Autre désignation: ING3 (ING3 Produits)

Synonymes: anticorps ING3, anticorps Eaf4, anticorps ING2, anticorps MEAF4, anticorps p47ING3, anticorps 1300013A07Rik, anticorps P47ING3, anticorps zgc:56327, anticorps inhibitor of growth family member 3, anticorps inhibitor of growth family, member 3, anticorps inhibitor of growth protein 3, anticorps inhibitor of growth family member 3 L homeolog, anticorps ING3, anticorps Ing3, anticorps CpipJ_CPIJ009396, anticorps ing3, anticorps ing3.L

Sujet: ING3 is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers.The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.
Alias Symbols: Eaf4, FLJ20089, ING2, p47ING3, MEAF4
Protein Interaction Partner: USHBP1, TRIM54, TEX11, FBXO25, APP, H2AFZ, ELAVL1, NR1H3, NR1H2, DMAP1, MORF4L1, KAT5, RBX1, RUVBL1, CUL1, TRRAP, UBC, SKP2, ACTL6A, EPC1, HHT2, HHT1, MEAF6, EPC2, BRD8, RUVBL2, YEATS4,
Protein Size: 418

Poids moléculaire: 47 kDa

ID gène: 54556

NCBI Accession: NM_019071, NP_061944

UniProt: Q9NXR8