STAT4 anticorps (N-Term)

N° du produit ABIN2777897

Détail du produit anti-STAT4 anticorps

Antigène: STAT4 (Signal Transducer and Activator of Transcription 4 (STAT4))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Porc, Chien, Lapin, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STAT4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: IGGPLHNGLD QLQNCFTLLA ESLFQLRRQL EKLEEQSTKM TYEGDPIPMQ

Homologie: Dog: 100%, Horse: 100%, Human: 100%, Mouse: 92%, Pig: 100%, Rabbit: 100%, Rat: 92%

Attributs du produit: This is a rabbit polyclonal antibody against STAT4. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human STAT4

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 748 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-STAT4 (ABIN2777897)

Torpey, Maher, Bothwell, Pober: "Interferon alpha but not interleukin 12 activates STAT4 signaling in human vascular endothelial cells." dans: The Journal of biological chemistry, Vol. 279, Issue 25, pp. 26789-96, (2004) (PubMed).

Détails sur STAT4

Antigène: STAT4 (Signal Transducer and Activator of Transcription 4 (STAT4))

Autre désignation: STAT4 (STAT4 Produits)

Synonymes: anticorps SLEB11, anticorps signal transducer and activator of transcription 4, anticorps STAT4, anticorps stat4, anticorps Stat4

Sujet: STAT4 is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells.
Alias Symbols: SLEB11
Protein Interaction Partner: UBC, ADRB2, TRIM28, FHL1, ZNF467, PIAS2, NMI, IL12RB2, IL12RB1, MAP2K6, STAT4, MAPK14, CREBBP, JUN, STAT3, IFNGR1,
Protein Size: 748

Poids moléculaire: 86 kDa

ID gène: 6775

NCBI Accession: NM_003151, NP_003142

UniProt: Q14765

Pathways: Signalistation JAK/STAT