Claudin 16 anticorps (C-Term)

N° du produit ABIN2778049

Détail du produit anti-Claudin 16 anticorps

Antigène: Claudin 16 (CLDN16)

Épitope: C-Term

Reactivité: Humain, Souris, Porc, Rat, Boeuf (Vache), Chien, Lapin, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Claudin 16 est non-conjugé

Application: Western Blotting (WB)

Séquence: FLAGAVLTCC LYLFKDVGPE RNYPYSLRKA YSAAGVSMAK SYSAPRTETA

Homologie: Cow: 86%, Dog: 86%, Horse: 93%, Human: 100%, Mouse: 86%, Pig: 86%, Rabbit: 93%, Rat: 86%

Attributs du produit: This is a rabbit polyclonal antibody against CLDN16. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human CLDN16

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 305 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-Claudin 16 (ABIN2778049)

Peng, Rao, Adelman, Rizzolo: "Claudin-19 and the barrier properties of the human retinal pigment epithelium." dans: Investigative ophthalmology & visual science, Vol. 52, Issue 3, pp. 1392-403, (2011) (PubMed).

Wang, Zhang, Maminishkis, Dong, Zhi, Li, Zhao, Majerciak, Gaur, Chen, Miller: "MicroRNA-204/211 alters epithelial physiology." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 24, Issue 5, pp. 1552-71, (2010) (PubMed).

Détails sur Claudin 16

Antigène: Claudin 16 (CLDN16)

Autre désignation: CLDN16 (CLDN16 Produits)

Synonymes: anticorps CLDN16, anticorps HOMG3, anticorps PCLN1, anticorps claudin-16, anticorps Pcln1, anticorps claudin 16, anticorps CLDN16, anticorps Cldn16

Sujet: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. Claudin-16, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in the corresponding gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure.Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: HOMG3, PCLN1
Protein Interaction Partner: APP, TJP1,
Protein Size: 305

Poids moléculaire: 34 kDa

ID gène: 10686

NCBI Accession: NM_006580, NP_006571

UniProt: Q9Y5I7

Pathways: Hepatitis C