PARP16 anticorps (Middle Region)

N° du produit ABIN2778107

Détail du produit anti-PARP16 anticorps

Antigène: PARP16 (Poly (ADP-Ribose) Polymerase Family, Member 16 (PARP16))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Cobaye, Cheval, Porc, Lapin, Boeuf (Vache), Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PARP16 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: PKYFVVTNNQ LLRVKYLLVY SQKPPKSRAS SQLSWFSSHW FTVMISLYLL

Homologie: Cow: 79%, Dog: 86%, Guinea Pig: 79%, Horse: 86%, Human: 100%, Mouse: 86%, Pig: 80%, Rabbit: 86%, Rat: 86%

Attributs du produit: This is a rabbit polyclonal antibody against PARP16. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human PARP16

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 323 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-PARP16 (ABIN2778107)

Di Paola, Micaroni, Di Tullio, Buccione, Di Girolamo: "PARP16/ARTD15 is a novel endoplasmic-reticulum-associated mono-ADP-ribosyltransferase that interacts with, and modifies karyopherin-ß1." dans: PLoS ONE, Vol. 7, Issue 6, pp. e37352, (2012) (PubMed).

Détails sur PARP16

Antigène: PARP16 (Poly (ADP-Ribose) Polymerase Family, Member 16 (PARP16))

Autre désignation: PARP16 (PARP16 Produits)

Synonymes: anticorps PARP16, anticorps zgc:77744, anticorps ARTD15, anticorps C15orf30, anticorps pART15, anticorps BC055447, anticorps C79952, anticorps PARP-16, anticorps LRRGT00109, anticorps RGD1306243, anticorps poly(ADP-ribose) polymerase family member 16, anticorps poly(ADP-ribose) polymerase family member 16 L homeolog, anticorps poly (ADP-ribose) polymerase family, member 16, anticorps PARP16, anticorps parp16.L, anticorps parp16, anticorps Parp16

Sujet: Poly(ADP-ribosyl)ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. PARP16 is a member of poly(ADP-ribose) polymerases (PARPs) family that is encoded by different genes and displaying a conserved catalytic domain in which PARP-1 (113 kDa), the founding member, and PARP-2 (62 kDa) are so far the sole enzymes whose catalytic activity has been shown to be immediately stimulated by DNA strand breaks. A large repertoire of sequences encoding novel PARPs now extends considerably the field of poly(ADP-ribosyl)ation reactions to various aspects of the cell biology including cell proliferation and cell death. Some of these new members interact with each other, share common partners and common subcellular localizations suggesting possible fine tuning in the regulation of this post-translational modification of proteins.
Alias Symbols: C15orf30, FLJ20509, FLJ25281, pART15
Protein Interaction Partner: GMCL1, UBC, NEDD4,
Protein Size: 323

Poids moléculaire: 36 kDa

ID gène: 54956

NCBI Accession: NM_017851, NP_060321