XRCC4 anticorps (Middle Region)
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- Antigène Voir toutes XRCC4 Anticorps
- XRCC4 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 (XRCC4))
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Épitope
- Middle Region
- Reactivité
- Humain, Rat, Souris, Boeuf (Vache), Cobaye, Cheval, Poisson zèbre (Danio rerio), Chien, Lapin, Saccharomyces cerevisiae
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp XRCC4 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- LQKENERLLR DWNDVQGRFE KCVSAKEALE TDLYKRFILV LNEKKTKIRS
- Homologie
- Cow: 100%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 92%, Rabbit: 92%, Rat: 92%, Yeast: 77%, Zebrafish: 85%
- Attributs du produit
- This is a rabbit polyclonal antibody against XRCC4. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the middle region of human XRCC4
- Top Product
- Discover our top product XRCC4 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 336 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- XRCC4 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 (XRCC4))
- Autre désignation
- XRCC4 (XRCC4 Produits)
- Synonymes
- anticorps zgc:73312, anticorps MGC81443, anticorps homolog of human DNA ligase iv-binding protein XRCC4, anticorps 2310057B22Rik, anticorps AW413319, anticorps AW545101, anticorps X-ray repair cross complementing 4, anticorps X-ray repair complementing defective repair in Chinese hamster cells 4, anticorps X-ray repair complementing defective repair in Chinese hamster cells 4 L homeolog, anticorps DNA ligase IV-binding protein, anticorps XRCC4, anticorps xrcc4, anticorps xrcc4.L, anticorps Xrcc4
- Sujet
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XRCC4 functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes.The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. This gene contains 8 exons, and alternative transcription initiation and alternative splicing generates several transcript variants.
Alias Symbols: -
Protein Interaction Partner: BIN1, FAM9B, ASTE1, XRCC4, LIG4, PNKP, PRKDC, CSNK2A1, VPS41, NUDT21, CWC27, DENR, USP7, SRP54, DDX5, APTX, ERG, SUMO2, UBC, CALM1, XRCC5, XRCC6, SETMAR, AHNAK, CAAP1, IFFO1, APLF, CHD3, NHEJ1, VIM, GZMB, ACTN1, NBN,
Protein Size: 336 - Poids moléculaire
- 38 kDa
- ID gène
- 7518
- NCBI Accession
- NM_022406, NP_071801
- UniProt
- Q13426
- Pathways
- Réparation de l'ADN, Production of Molecular Mediator of Immune Response
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