COPS2 anticorps (N-Term)

N° du produit ABIN2778315

Détail du produit anti-COPS2 anticorps

Antigène: COPS2 (COP9 Constitutive Photomorphogenic Homolog Subunit 2 (Arabidopsis) (COPS2))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Poisson zèbre (Danio rerio), Cheval, Cobaye, Lapin, Saccharomyces cerevisiae

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp COPS2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: SDMEDDFMCD DEEDYDLEYS EDSNSEPNVD LENQYYNSKA LKEDDPKAAL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 85%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against COPS2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human COPS2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 443 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur COPS2

Antigène: COPS2 (COP9 Constitutive Photomorphogenic Homolog Subunit 2 (Arabidopsis) (COPS2))

Autre désignation: COPS2 (COPS2 Produits)

Synonymes: anticorps COPS2, anticorps ALIEN, anticorps CSN2, anticorps SGN2, anticorps TRIP15, anticorps wu:fc05f05, anticorps wu:fc06g10, anticorps wu:fc60f04, anticorps wu:fl94f12, anticorps zgc:86624, anticorps csn2, anticorps Tb03.48O8.600, anticorps Trip15, anticorps AI315723, anticorps C85265, anticorps Csn2, anticorps Sgn2, anticorps alien-like, anticorps ATCSN2, anticorps CONSTITUTIVE PHOTOMORPHOGENIC 12, anticorps COP12, anticorps FUSCA 12, anticorps T20P8.4, anticorps T20P8_4, anticorps COP9 signalosome subunit 2, anticorps COP9 signalosome subunit 2 L homeolog, anticorps COP9 signalosome complex subunit 2, anticorps COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis), anticorps proteasome family protein, anticorps COPS2, anticorps cops2, anticorps cops2.L, anticorps Tb927.3.2320, anticorps AOR_1_576084, anticorps PTRG_07106, anticorps LOC100283498, anticorps Cops2, anticorps csn-2, anticorps FUS12

Sujet: COPS2 is an essential component of the COP9 signalosome complex (CSN). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. COPS2 is involved in early stage of neuronal differentiation via its interaction with NIF3L1.
Alias Symbols: ALIEN, CSN2, SGN2, TRIP15
Protein Interaction Partner: UBC, GPS1, Map3k10, 5830415F09Rik, Taf1b, EP300, Crebbp, cul1, COPS7B, EPB41L1, COPS5, FBXW4, SENP8, vpr, IRF5, COPS4, COPS7A, COPS6, COPS8, COPS3, PMPCA, SEPHS1, EHBP1L1, SLAIN2, GAPVD1, PFKFB2, SEPT2, IRS2, GRK5, DDB2, LRR1, DCAF11, DDA1, RFWD2, DCAF8,
Protein Size: 443

Poids moléculaire: 52 kDa

ID gène: 9318

NCBI Accession: NM_004236, NP_004227

UniProt: P61201

Pathways: Cycle Cellulaire