PHD1 anticorps (Middle Region)

N° du produit ABIN2778438

Détail du produit anti-PHD1 anticorps

Antigène: PHD1 (EGLN2) (Egl-9 Family Hypoxia Inducible Factor 2 (EGLN2))

Épitope: Middle Region

Reactivité: Humain, Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PHD1 est non-conjugé

Application: Western Blotting (WB)

Séquence: AVLDGSELSY FGQEGMTEVQ CGKVAFQFQC SSDSTNGTGV QGGQIPELIF

Homologie: Dog: 85%, Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against EGLN2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human EGLN2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 407 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-PHD1 (ABIN2778438)

Tennant, Frezza, MacKenzie, Nguyen, Zheng, Selak, Roberts, Dive, Watson, Aboagye, Gottlieb: "Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death." dans: Oncogene, Vol. 28, Issue 45, pp. 4009-21, (2009) (PubMed).

Détails sur PHD1

Antigène: PHD1 (EGLN2) (Egl-9 Family Hypoxia Inducible Factor 2 (EGLN2))

Autre désignation: EGLN2 (EGLN2 Produits)

Synonymes: anticorps egln2, anticorps phd2, anticorps PHD1, anticorps 0610011A13Rik, anticorps C85656, anticorps Hif-p4h-1, anticorps Ier4, anticorps Phd1, anticorps SM-20, anticorps HIF-PH1, anticorps HPH-1, anticorps HPH-3, anticorps PHD-1, anticorps EIT6, anticorps HIFPH1, anticorps egl-9 family hypoxia-inducible factor 1, anticorps egl-9 family hypoxia inducible factor 2, anticorps Egl nine homolog 2, anticorps egl-9 family hypoxia-inducible factor 2 L homeolog, anticorps egl-9 family hypoxia-inducible factor 2, anticorps egln1, anticorps EGLN2, anticorps egln2, anticorps egln2.L, anticorps Egln2

Sujet: The hypoxia inducible factor (HIF) is a transcriptional complex which is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. EGLN2 encodes an enzyme responsible for this posttranslational modification. Alternative splicing of EGLN2 results in three transcript variants encoding different isoforms. The hypoxia inducible factor (HIF) is a transcriptional complex which is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. This gene encodes an enzyme responsible for this posttranslational modification. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Alias Symbols: DKFZp434E026, EIT6, HIFPH1, HPH-3, PHD1, HPH-1, HIF-PH1
Protein Interaction Partner: SRPK2, CEP192, IKBKG, FAM46A, EPAS1, A2M, MAGEA11, SIAH2, LPP, WTIP, AJUBA, LIMD1, TRIP6, SPRY2, PRPF19, EGLN3, EGLN2, HIF1A, HIF3A, MOB4, POLR2A,
Protein Size: 407

Poids moléculaire: 44 kDa

ID gène: 112398

NCBI Accession: NM_053046, NP_444274

UniProt: Q96KS0

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Cell RedoxHomeostasis