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PHD1 anticorps (Middle Region)

EGLN2 Reactivité: Humain, Chien WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2778438
  • Antigène Voir toutes PHD1 (EGLN2) Anticorps
    PHD1 (EGLN2) (Egl-9 Family Hypoxia Inducible Factor 2 (EGLN2))
    Épitope
    • 15
    • 11
    • 8
    • 6
    • 5
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivité
    • 57
    • 33
    • 19
    • 7
    • 7
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain, Chien
    Hôte
    • 68
    • 3
    • 1
    Lapin
    Clonalité
    • 68
    • 4
    Polyclonal
    Conjugué
    • 28
    • 7
    • 7
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PHD1 est non-conjugé
    Application
    • 61
    • 35
    • 16
    • 14
    • 13
    • 7
    • 7
    • 3
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB)
    Séquence
    AVLDGSELSY FGQEGMTEVQ CGKVAFQFQC SSDSTNGTGV QGGQIPELIF
    Homologie
    Dog: 85%, Human: 100%
    Attributs du produit
    This is a rabbit polyclonal antibody against EGLN2. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the middle region of human EGLN2
    Top Product
    Discover our top product EGLN2 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 407 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Tennant, Frezza, MacKenzie, Nguyen, Zheng, Selak, Roberts, Dive, Watson, Aboagye, Gottlieb: "Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death." dans: Oncogene, Vol. 28, Issue 45, pp. 4009-21, (2009) (PubMed).

  • Antigène
    PHD1 (EGLN2) (Egl-9 Family Hypoxia Inducible Factor 2 (EGLN2))
    Autre désignation
    EGLN2 (EGLN2 Produits)
    Synonymes
    anticorps egln2, anticorps phd2, anticorps PHD1, anticorps 0610011A13Rik, anticorps C85656, anticorps Hif-p4h-1, anticorps Ier4, anticorps Phd1, anticorps SM-20, anticorps HIF-PH1, anticorps HPH-1, anticorps HPH-3, anticorps PHD-1, anticorps EIT6, anticorps HIFPH1, anticorps egl-9 family hypoxia-inducible factor 1, anticorps egl-9 family hypoxia inducible factor 2, anticorps Egl nine homolog 2, anticorps egl-9 family hypoxia-inducible factor 2 L homeolog, anticorps egl-9 family hypoxia-inducible factor 2, anticorps egln1, anticorps EGLN2, anticorps egln2, anticorps egln2.L, anticorps Egln2
    Sujet
    The hypoxia inducible factor (HIF) is a transcriptional complex which is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. EGLN2 encodes an enzyme responsible for this posttranslational modification. Alternative splicing of EGLN2 results in three transcript variants encoding different isoforms. The hypoxia inducible factor (HIF) is a transcriptional complex which is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. This gene encodes an enzyme responsible for this posttranslational modification. Multiple alternatively spliced variants, encoding the same protein, have been identified.
    Alias Symbols: DKFZp434E026, EIT6, HIFPH1, HPH-3, PHD1, HPH-1, HIF-PH1
    Protein Interaction Partner: SRPK2, CEP192, IKBKG, FAM46A, EPAS1, A2M, MAGEA11, SIAH2, LPP, WTIP, AJUBA, LIMD1, TRIP6, SPRY2, PRPF19, EGLN3, EGLN2, HIF1A, HIF3A, MOB4, POLR2A,
    Protein Size: 407
    Poids moléculaire
    44 kDa
    ID gène
    112398
    NCBI Accession
    NM_053046, NP_444274
    UniProt
    Q96KS0
    Pathways
    Intracellular Steroid Hormone Receptor Signaling Pathway, Cell RedoxHomeostasis
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