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Aprataxin anticorps (C-Term)

APTX Reactivité: Humain, Souris, Rat, Cobaye, Chien, Lapin, Cheval, Boeuf (Vache) IHC, WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2778569
  • Antigène Voir toutes Aprataxin (APTX) Anticorps
    Aprataxin (APTX)
    Épitope
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 28
    • 13
    • 13
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Cobaye, Chien, Lapin, Cheval, Boeuf (Vache)
    Hôte
    • 24
    • 4
    Lapin
    Clonalité
    • 26
    • 2
    Polyclonal
    Conjugué
    • 17
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Aprataxin est non-conjugé
    Application
    • 15
    • 9
    • 7
    • 6
    • 3
    • 2
    • 1
    • 1
    Immunohistochemistry (IHC), Western Blotting (WB)
    Séquence
    VIEMVQEAGR VTVRDGMPEL LKLPLRCHEC QQLLPSIPQL KEHLRKHWTQ
    Homologie
    Cow: 100%, Dog: 92%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
    Attributs du produit
    This is a rabbit polyclonal antibody against APTX. It was validated on Western Blot and immunohistochemistry.
    Purification
    Protein A purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the C terminal region of human APTX
    Top Product
    Discover our top product APTX Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 342 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Dopeso, Mateo-Lozano, Elez, Landolfi, Ramos Pascual, Hernández-Losa, Mazzolini, Rodrigues, Bazzocco, Carreras, Espín, Armengol, Wilson, Mariadason, Ramon Y Cajal, Tabernero, Schwartz, Arango: "Aprataxin tumor levels predict response of colorectal cancer patients to irinotecan-based treatment." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 16, Issue 8, pp. 2375-82, (2010) (PubMed).

  • Antigène
    Aprataxin (APTX)
    Autre désignation
    APTX (APTX Produits)
    Synonymes
    anticorps aptx, anticorps APTX, anticorps LOC100284636, anticorps APRATAXIN-like, anticorps T10O8.20, anticorps T10O8_20, anticorps AOA, anticorps AOA1, anticorps AXA1, anticorps EAOH, anticorps EOAHA, anticorps FHA-HIT, anticorps 2410016G21Rik, anticorps AA388047, anticorps aprataxin, anticorps FHA-HIT, anticorps APRATAXIN-like protein, anticorps aprataxin L homeolog, anticorps aptx, anticorps APTX, anticorps CpipJ_CPIJ001673, anticorps LOC100284636, anticorps aptx.L, anticorps Aptx
    Sujet
    APTX is a member of the histidine triad (HIT) superfamily, some of which have nucleotide-binding and diadenosine polyphosphate hydrolase activities. APTX may play a role in single-stranded DNA repair. Mutations in this gene have been associated with ataxia-ocular apraxia.This gene encodes a member of the histidine triad (HIT) superfamily, some of which have nucleotide-binding and diadenosine polyphosphate hydrolase activities. The encoded protein may play a role in single-stranded DNA repair. Mutations in this gene have been associated with ataxia-ocular apraxia. Multiple transcript variants encoding distinct isoforms have been identified for this gene, however, the full length nature of some variants has not been determined.This gene encodes a member of the histidine triad (HIT) superfamily, some of which have nucleotide-binding and diadenosine polyphosphate hydrolase activities. The encoded protein may play a role in single-stranded DNA repair. Mutations in this gene have been associated with ataxia-ocular apraxia. Multiple transcript variants encoding distinct isoforms have been identified for this gene, however, the full length nature of some variants has not been determined.
    Alias Symbols: AOA, AOA1, AXA1, EAOH, EOAHA, FHA-HIT
    Protein Interaction Partner: PNMA1, UBC, SUMO1, NEDD8, LIG3, HSPA4, XRCC1, DDX21, CNTROB, TSPYL2, CALCOCO1, SYT17, ZNF639, MAPKBP1, CEP350, PICK1, XRCC4, TRIM37, MBP, HIVEP1, BANF1, PARP1, TP53,
    Protein Size: 342
    Poids moléculaire
    38 kDa
    ID gène
    54840
    NCBI Accession
    NM_175073, NP_778243
    UniProt
    Q6JV85
    Pathways
    Réparation de l'ADN, Chromatin Binding
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