Aprataxin anticorps (C-Term)
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- Antigène Voir toutes Aprataxin (APTX) Anticorps
- Aprataxin (APTX)
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Épitope
- C-Term
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Reactivité
- Humain, Souris, Rat, Cobaye, Chien, Lapin, Cheval, Boeuf (Vache)
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Aprataxin est non-conjugé
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Application
- Immunohistochemistry (IHC), Western Blotting (WB)
- Séquence
- VIEMVQEAGR VTVRDGMPEL LKLPLRCHEC QQLLPSIPQL KEHLRKHWTQ
- Homologie
- Cow: 100%, Dog: 92%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against APTX. It was validated on Western Blot and immunohistochemistry.
- Purification
- Protein A purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the C terminal region of human APTX
- Top Product
- Discover our top product APTX Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 342 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Aprataxin tumor levels predict response of colorectal cancer patients to irinotecan-based treatment." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 16, Issue 8, pp. 2375-82, (2010) (PubMed).
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Aprataxin tumor levels predict response of colorectal cancer patients to irinotecan-based treatment." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 16, Issue 8, pp. 2375-82, (2010) (PubMed).
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- Antigène
- Aprataxin (APTX)
- Autre désignation
- APTX (APTX Produits)
- Synonymes
- anticorps aptx, anticorps APTX, anticorps LOC100284636, anticorps APRATAXIN-like, anticorps T10O8.20, anticorps T10O8_20, anticorps AOA, anticorps AOA1, anticorps AXA1, anticorps EAOH, anticorps EOAHA, anticorps FHA-HIT, anticorps 2410016G21Rik, anticorps AA388047, anticorps aprataxin, anticorps FHA-HIT, anticorps APRATAXIN-like protein, anticorps aprataxin L homeolog, anticorps aptx, anticorps APTX, anticorps CpipJ_CPIJ001673, anticorps LOC100284636, anticorps aptx.L, anticorps Aptx
- Sujet
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APTX is a member of the histidine triad (HIT) superfamily, some of which have nucleotide-binding and diadenosine polyphosphate hydrolase activities. APTX may play a role in single-stranded DNA repair. Mutations in this gene have been associated with ataxia-ocular apraxia.This gene encodes a member of the histidine triad (HIT) superfamily, some of which have nucleotide-binding and diadenosine polyphosphate hydrolase activities. The encoded protein may play a role in single-stranded DNA repair. Mutations in this gene have been associated with ataxia-ocular apraxia. Multiple transcript variants encoding distinct isoforms have been identified for this gene, however, the full length nature of some variants has not been determined.This gene encodes a member of the histidine triad (HIT) superfamily, some of which have nucleotide-binding and diadenosine polyphosphate hydrolase activities. The encoded protein may play a role in single-stranded DNA repair. Mutations in this gene have been associated with ataxia-ocular apraxia. Multiple transcript variants encoding distinct isoforms have been identified for this gene, however, the full length nature of some variants has not been determined.
Alias Symbols: AOA, AOA1, AXA1, EAOH, EOAHA, FHA-HIT
Protein Interaction Partner: PNMA1, UBC, SUMO1, NEDD8, LIG3, HSPA4, XRCC1, DDX21, CNTROB, TSPYL2, CALCOCO1, SYT17, ZNF639, MAPKBP1, CEP350, PICK1, XRCC4, TRIM37, MBP, HIVEP1, BANF1, PARP1, TP53,
Protein Size: 342 - Poids moléculaire
- 38 kDa
- ID gène
- 54840
- NCBI Accession
- NM_175073, NP_778243
- UniProt
- Q6JV85
- Pathways
- Réparation de l'ADN, Chromatin Binding
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