Aprataxin anticorps (C-Term)

N° du produit ABIN2778569

Détail du produit anti-Aprataxin anticorps

Antigène: Aprataxin (APTX)

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Cobaye, Chien, Cheval, Lapin, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Aprataxin est non-conjugé

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Séquence: VIEMVQEAGR VTVRDGMPEL LKLPLRCHEC QQLLPSIPQL KEHLRKHWTQ

Homologie: Cow: 100%, Dog: 92%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against APTX. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human APTX

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 342 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-Aprataxin (ABIN2778569)

Dopeso, Mateo-Lozano, Elez, Landolfi, Ramos Pascual, Hernández-Losa, Mazzolini, Rodrigues, Bazzocco, Carreras, Espín, Armengol, Wilson, Mariadason, Ramon Y Cajal, Tabernero, Schwartz, Arango: "Aprataxin tumor levels predict response of colorectal cancer patients to irinotecan-based treatment." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 16, Issue 8, pp. 2375-82, (2010) (PubMed).

Détails sur Aprataxin

Antigène: Aprataxin (APTX)

Autre désignation: APTX (APTX Produits)

Synonymes: anticorps aptx, anticorps APTX, anticorps LOC100284636, anticorps APRATAXIN-like, anticorps T10O8.20, anticorps T10O8_20, anticorps AOA, anticorps AOA1, anticorps AXA1, anticorps EAOH, anticorps EOAHA, anticorps FHA-HIT, anticorps 2410016G21Rik, anticorps AA388047, anticorps aprataxin, anticorps FHA-HIT, anticorps APRATAXIN-like protein, anticorps aprataxin L homeolog, anticorps aptx, anticorps APTX, anticorps CpipJ_CPIJ001673, anticorps LOC100284636, anticorps aptx.L, anticorps Aptx

Sujet: APTX is a member of the histidine triad (HIT) superfamily, some of which have nucleotide-binding and diadenosine polyphosphate hydrolase activities. APTX may play a role in single-stranded DNA repair. Mutations in this gene have been associated with ataxia-ocular apraxia.This gene encodes a member of the histidine triad (HIT) superfamily, some of which have nucleotide-binding and diadenosine polyphosphate hydrolase activities. The encoded protein may play a role in single-stranded DNA repair. Mutations in this gene have been associated with ataxia-ocular apraxia. Multiple transcript variants encoding distinct isoforms have been identified for this gene, however, the full length nature of some variants has not been determined.This gene encodes a member of the histidine triad (HIT) superfamily, some of which have nucleotide-binding and diadenosine polyphosphate hydrolase activities. The encoded protein may play a role in single-stranded DNA repair. Mutations in this gene have been associated with ataxia-ocular apraxia. Multiple transcript variants encoding distinct isoforms have been identified for this gene, however, the full length nature of some variants has not been determined.
Alias Symbols: AOA, AOA1, AXA1, EAOH, EOAHA, FHA-HIT
Protein Interaction Partner: PNMA1, UBC, SUMO1, NEDD8, LIG3, HSPA4, XRCC1, DDX21, CNTROB, TSPYL2, CALCOCO1, SYT17, ZNF639, MAPKBP1, CEP350, PICK1, XRCC4, TRIM37, MBP, HIVEP1, BANF1, PARP1, TP53,
Protein Size: 342

Poids moléculaire: 38 kDa

ID gène: 54840

NCBI Accession: NM_175073, NP_778243

UniProt: Q6JV85

Pathways: Réparation de l'ADN, Chromatin Binding