HNRNPA1 anticorps (N-Term)

N° du produit ABIN2778789

Détail du produit anti-HNRNPA1 anticorps

Antigène: HNRNPA1 (Heterogeneous Nuclear Ribonucleoprotein A1 (HNRNPA1))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cheval, Cobaye, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HNRNPA1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: MSKSESPKEP EQLRKLFIGG LSFETTDESL RSHFEQWGTL TDCVVMRDPN

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against HNRPA1. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human HNRPA1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 320 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-HNRNPA1 (ABIN2778789)

Li, Wang, Ding, Xu, Zhao, Li, Li, Xia, Su, Chen, Fang, Shao, Zhang: "Aptamer BC15 against heterogeneous nuclear ribonucleoprotein A1 has potential value in diagnosis and therapy of hepatocarcinoma." dans: Nucleic acid therapeutics, Vol. 22, Issue 6, pp. 391-8, (2012) (PubMed).

Stark, Bram, Akerman, Mandel-Gutfreund, Assaraf: "Heterogeneous nuclear ribonucleoprotein H1/H2-dependent unsplicing of thymidine phosphorylase results in anticancer drug resistance." dans: The Journal of biological chemistry, Vol. 286, Issue 5, pp. 3741-54, (2011) (PubMed).

Gonen, Assaraf: "The obligatory intestinal folate transporter PCFT (SLC46A1) is regulated by nuclear respiratory factor 1." dans: The Journal of biological chemistry, Vol. 285, Issue 44, pp. 33602-13, (2010) (PubMed).

Li, Xu, Ding, Huang, Cao, Yang, Li, Xie, Meng, Li, Zhao, Shen, Shao: "Identification of an aptamer targeting hnRNP A1 by tissue slide-based SELEX." dans: The Journal of pathology, Vol. 218, Issue 3, pp. 327-36, (2009) (PubMed).

Détails sur HNRNPA1

Antigène: HNRNPA1 (Heterogeneous Nuclear Ribonucleoprotein A1 (HNRNPA1))

Autre désignation: HNRPA1 (HNRNPA1 Produits)

Synonymes: anticorps HNRPA1, anticorps HNRPA1L3, anticorps hnRNP A1, anticorps hnRNP-A1, anticorps hnrpa1, anticorps TPT1P, anticorps HNRNPA1, anticorps D15Ertd119e, anticorps Hdp, anticorps Hnrpa1, anticorps hnrnp-A1, anticorps ROA1, anticorps zgc:66127, anticorps heterogeneous nuclear ribonucleoprotein A1, anticorps heterogeneous nuclear ribonucleoprotein A1b, anticorps Heterogeneous nuclear ribonucleoprotein A1, anticorps heterogeneous nuclear ribonucleoprotein A1 S homeolog, anticorps ribonucleoprotein A1a, anticorps heterogeneous nuclear ribonucleoprotein A1-like, anticorps heterogeneous nuclear ribonucleoprotein A1a, anticorps HNRNPA1, anticorps hnrnpa1b, anticorps LOC100101226, anticorps roa1, anticorps Hnrnpa1, anticorps hnrnpa1.S, anticorps hnrnpa1, anticorps LOC100359118, anticorps hnrnpa1a

Sujet: HNRPA1 belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). HNRPA1 has two repeats of quasi-RRM domains that bind to RNAs. It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm. HNRPA1 is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly A+ mRNA from the nucleus to the cytoplasm, and may modulate splice site selection. It is also thought have a primary role in the formation of specific myometrial protein species in parturition. This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm. This protein, along with other hnRNP proteins, is exported from the nucleus, probably bound to mRNA, and is immediately re-imported. Its M9 domain acts as both a nuclear localization and nuclear export signal. The encoded protein is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly A+ mRNA from the nucleus to the cytoplasm, and may modulate splice site selection. It is also thought have a primary role in the formation of specific myometrial protein species in parturition. Multiple alternatively spliced transcript variants have been found for this gene but only two transcripts are fully described. These variants have multiple alternative transcription initiation sites and multiple polyA sites.
Alias Symbols: HNRPA1, HNRPA1L3, hnRNP A1, hnRNP-A1
Protein Interaction Partner: UBC, TP53, PSMD9, TUBGCP3, NEDD1, AURKB, AURKA, STAU1, IVNS1ABP, TNF, PSMB4, MDM2, CHUK, RPA3, RPA2, RPA1, ASB2, ERG, EED, RNF2, rev, IQGAP1, HIST1H2AB, AIMP2, RPL38, RPL27A, QARS, DHX9, CCAR2, ZC3HC1, HNRNPU, PARK2, FBXO6, TARDBP, YWHAQ, SRPK1, XRN1, CSF
Protein Size: 320

Poids moléculaire: 35 kDa

ID gène: 3178

NCBI Accession: NM_002136, NP_002127

UniProt: Q6IPF2