Aconitase 1 anticorps (N-Term)

N° du produit ABIN2778793

Détail du produit anti-Aconitase 1 anticorps

Antigène: Aconitase 1 (ACO1)

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Lapin, Chien, Cobaye, Cheval, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Aconitase 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: MSNPFAHLAE PLDPVQPGKK FFNLNKLEDS RYGRLPFSIR VLLEAAIRNC

Homologie: Cow: 100%, Dog: 93%, Guinea Pig: 91%, Horse: 92%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 86%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against ACO1. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human ACO1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 889 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Aconitase 1

Antigène: Aconitase 1 (ACO1)

Autre désignation: ACO1 (ACO1 Produits)

Synonymes: anticorps ACONS, anticorps IREB1, anticorps IREBP, anticorps IREBP1, anticorps IRP1, anticorps Acon1, anticorps Ratireb, anticorps ratireb, anticorps Aco1, anticorps AI256519, anticorps Aco-1, anticorps Irebp, anticorps Irp1, anticorps aconitase 1, anticorps aconitase 1, soluble, anticorps aconitase 1 L homeolog, anticorps ACO1, anticorps Aco1, anticorps aco1.L

Sujet: ACO1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). It plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.
Alias Symbols: IRP1, ACONS, IREB1, IREBP, IREBP1
Protein Interaction Partner: UBC, FBXL5, DCPS, STRAP, FUBP1, PSMG1, HIST1H2AB, LGALS1, CTPS1, C12orf57, APP, AKT1,
Protein Size: 889

Poids moléculaire: 98 kDa

ID gène: 48

NCBI Accession: NM_002197, NP_002188

UniProt: P28271

Pathways: Transition Metal Ion Homeostasis