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PABPC4 anticorps (N-Term)

PABPC4 Reactivité: Humain, Souris, Rat, Chien, Cobaye, Boeuf (Vache), Cheval, Lapin, Poisson zèbre (Danio rerio) WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2778874
  • Antigène Voir toutes PABPC4 Anticorps
    PABPC4 (Poly(A) Binding Protein, Cytoplasmic 4 (Inducible Form) (PABPC4))
    Épitope
    • 7
    • 7
    • 6
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 37
    • 13
    • 13
    • 6
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    Humain, Souris, Rat, Chien, Cobaye, Boeuf (Vache), Cheval, Lapin, Poisson zèbre (Danio rerio)
    Hôte
    • 36
    • 1
    Lapin
    Clonalité
    • 37
    Polyclonal
    Conjugué
    • 20
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PABPC4 est non-conjugé
    Application
    • 30
    • 17
    • 11
    • 7
    • 5
    • 3
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Séquence
    AELGAKAKEF TNVYIKNFGE EVDDESLKEL FSQFGKTLSV KVMRDPNGKS
    Homologie
    Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 86%, Rabbit: 93%, Rat: 100%, Zebrafish: 79%
    Attributs du produit
    This is a rabbit polyclonal antibody against PABPC4. It was validated on Western Blot and immunohistochemistry.
    Purification
    Protein A purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the N terminal region of human PABPC4
    Top Product
    Discover our top product PABPC4 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 644 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    PABPC4 (Poly(A) Binding Protein, Cytoplasmic 4 (Inducible Form) (PABPC4))
    Autre désignation
    PABPC4 (PABPC4 Produits)
    Synonymes
    anticorps cb12, anticorps sb:cb12, anticorps PABP, anticorps ePAB, anticorps ePABP, anticorps APP-1, anticorps APP1, anticorps PABP4, anticorps iPABP, anticorps polyadenylate-binding protein 4, anticorps poly(A) binding protein, cytoplasmic 4, anticorps poly(A) binding protein, cytoplasmic 4 (inducible form), anticorps poly(A) binding protein cytoplasmic 4 L homeolog, anticorps poly(A) binding protein cytoplasmic 4, anticorps Bm1_06880, anticorps Pabpc4, anticorps pabpc4, anticorps pabpc4.L, anticorps PABPC4
    Sujet
    Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules.Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules.
    Alias Symbols: APP1, APP-1, PABP4, iPABP
    Protein Interaction Partner: FBXW11, UBC, IVNS1ABP, STAU1, RPA3, RPA2, RPA1, WWOX, SUZ12, RNF2, EZH2, BMI1, NCAPD2, DDX5, TARDBP, SRPK2, CLK3, YWHAQ, UBD, EIF2AK2, PAN2, UBL4A, SMAD9, ITGA4, IL7R, IFIT3, IFIT1, IFIT2, FN1, IGBP1, NUBP2, CAND1, DCUN1D1, COPS5, CUL1, CUL2, CUL3, CUL4A,
    Protein Size: 644
    Poids moléculaire
    71 kDa
    ID gène
    8761
    NCBI Accession
    NM_003819, NP_003810
    UniProt
    Q13310
    Pathways
    SARS-CoV-2 Protein Interactome
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