PABPC4 anticorps (N-Term)

N° du produit ABIN2778874

Détail du produit anti-PABPC4 anticorps

Antigène: PABPC4 (Poly(A) Binding Protein, Cytoplasmic 4 (Inducible Form) (PABPC4))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Chien, Cobaye, Boeuf (Vache), Cheval, Lapin, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PABPC4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: AELGAKAKEF TNVYIKNFGE EVDDESLKEL FSQFGKTLSV KVMRDPNGKS

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 86%, Rabbit: 93%, Rat: 100%, Zebrafish: 79%

Attributs du produit: This is a rabbit polyclonal antibody against PABPC4. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human PABPC4

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 644 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur PABPC4

Antigène: PABPC4 (Poly(A) Binding Protein, Cytoplasmic 4 (Inducible Form) (PABPC4))

Autre désignation: PABPC4 (PABPC4 Produits)

Synonymes: anticorps cb12, anticorps sb:cb12, anticorps PABP, anticorps ePAB, anticorps ePABP, anticorps APP-1, anticorps APP1, anticorps PABP4, anticorps iPABP, anticorps polyadenylate-binding protein 4, anticorps poly(A) binding protein, cytoplasmic 4, anticorps poly(A) binding protein, cytoplasmic 4 (inducible form), anticorps poly(A) binding protein cytoplasmic 4 L homeolog, anticorps poly(A) binding protein cytoplasmic 4, anticorps Bm1_06880, anticorps Pabpc4, anticorps pabpc4, anticorps pabpc4.L, anticorps PABPC4

Sujet: Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules.Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules.
Alias Symbols: APP1, APP-1, PABP4, iPABP
Protein Interaction Partner: FBXW11, UBC, IVNS1ABP, STAU1, RPA3, RPA2, RPA1, WWOX, SUZ12, RNF2, EZH2, BMI1, NCAPD2, DDX5, TARDBP, SRPK2, CLK3, YWHAQ, UBD, EIF2AK2, PAN2, UBL4A, SMAD9, ITGA4, IL7R, IFIT3, IFIT1, IFIT2, FN1, IGBP1, NUBP2, CAND1, DCUN1D1, COPS5, CUL1, CUL2, CUL3, CUL4A,
Protein Size: 644

Poids moléculaire: 71 kDa

ID gène: 8761

NCBI Accession: NM_003819, NP_003810

UniProt: Q13310

Pathways: SARS-CoV-2 Protein Interactome