PCBP2 anticorps (Middle Region)

N° du produit ABIN2778923

Détail du produit anti-PCBP2 anticorps

Antigène: PCBP2 (Poly(rC) Binding Protein 2 (PCBP2))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Cobaye, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PCBP2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: VIFAGGQDRY STGSDSASFP HTTPSMCLNP DLEGPPLEAY TIQGQYAIPQ

Homologie: Cow: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against PCBP2. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human PCBP2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 366 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-PCBP2 (ABIN2778923)

Lin, Yang, Liu, Tan, Wu, Hu, Jiang, Bao, Yuan, Qiang, Peng, Han: "Interplay between PCBP2 and miRNA modulates ARHGDIA expression and function in glioma migration and invasion." dans: Oncotarget, Vol. 7, Issue 15, pp. 19483-98, (2016) (PubMed).

Han, Xin, Zhao, Bao, Lin, Yin, Zhao, Yuan, Qiang, Peng: "RNA-binding protein PCBP2 modulates glioma growth by regulating FHL3." dans: The Journal of clinical investigation, Vol. 123, Issue 5, pp. 2103-18, (2013) (PubMed).

Détails sur PCBP2

Antigène: PCBP2 (Poly(rC) Binding Protein 2 (PCBP2))

Autre désignation: PCBP2 (PCBP2 Produits)

Synonymes: anticorps HNRNPE2, anticorps HNRPE2, anticorps hnRNP-E2, anticorps AW412548, anticorps Hnrpx, anticorps alphaCP-2, anticorps PCBP3, anticorps fb36h02, anticorps wu:fb36h02, anticorps zgc:55964, anticorps PCBP2, anticorps poly(rC) binding protein 2, anticorps poly(rC) binding protein 2 L homeolog, anticorps PCBP2, anticorps Pcbp2, anticorps pcbp2, anticorps pcbp2.L

Sujet: PCBP2 appears to be multifunctional. It along with PCBP-1 and hnRNPK corresponds to the major cellular poly(rC)-binding proteins. This protein together with PCBP-1 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This gene and PCBP-1 has paralogues PCBP3 and PCBP4 which is thought to arose as a result of duplication events of entire genes.The protein encoded by this gene appears to be multifunctional. It along with PCBP-1 and hnRNPK corresponds to the major cellular poly(rC)-binding proteins. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-1 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1 intronless gene which has similar functions. This gene and PCBP-1 has paralogues PCBP3 and PCBP4 which is thought to arose as a result of duplication events of entire genes. It also has two processed pseudogenes PCBP2P1 and PCBP2P2. There are presently two alternatively spliced transcript variants described for this gene.
Alias Symbols: HNRPE2, hnRNP-E2
Protein Interaction Partner: FUS, HUWE1, UBC, SNRPA, SUMO2, SUMO3, CEP250, MDM2, EED, TARDBP, ADRB2, IGSF8, HMGA1, CD81, HMGA2, WDR83, SLU7, CASK, UBL4A, VCAM1, PCBP2, NOS2, ITGA4, FN1, BRCA1, PRPF40A, SF3B2, NKAP, WDR77, PAXIP1, BARD1, PPIB, EEF1A1, FBXO6, UBD, PCBP1, QKI, CDK2, COP
Protein Size: 366

Poids moléculaire: 40 kDa

ID gène: 5094

NCBI Accession: NM_005016, NP_005007

UniProt: Q6IPF4