SFPQ anticorps (Middle Region)

N° du produit ABIN2778924

Détail du produit anti-SFPQ anticorps

Antigène: SFPQ (Splicing Factor Proline/glutamine-Ric (SFPQ))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Cobaye, Lapin, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SFPQ est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: PVIVEPLEQL DDEDGLPEKL AQKNPMYQKE RETPPRFAQH GTFEYEYSQR

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

Attributs du produit: This is a rabbit polyclonal antibody against SFPQ. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human SFPQ

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 707 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur SFPQ

Antigène: SFPQ (Splicing Factor Proline/glutamine-Ric (SFPQ))

Autre désignation: SFPQ (SFPQ Produits)

Synonymes: anticorps 1110004P21Rik, anticorps 2810416M14Rik, anticorps 5730453G22Rik, anticorps 9030402K04Rik, anticorps AU021830, anticorps D4Ertd314e, anticorps Gm12940, anticorps OTTMUSG00000009329, anticorps PSF, anticorps REP1, anticorps hm:zeh0027, anticorps wu:fa11h12, anticorps wu:fd10f03, anticorps zgc:85935, anticorps POMP100, anticorps splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated), anticorps splicing factor proline/glutamine-rich, anticorps splicing factor proline and glutamine rich, anticorps Sfpq, anticorps sfpq, anticorps SFPQ

Sujet: SFPQ is DNA- and RNA binding protein. It is essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as an heteromer with NONO. It binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. It interacts with U5 snRNA. It may be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. SFPQ may be involved in homologous DNA pairing. SFPQ is involved in transcriptional regulation. It binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF-I-stimulated transcriptional activity.
Alias Symbols: POMP100, PSF
Protein Interaction Partner: SNRPA, PTBP1, NONO, HDAC2, FUS, HUWE1, UBC, SUMO2, MDM2, STAU1, RPA3, RPA2, RPA1, ERG, ASB18, ASB12, WWOX, ASB3, EED, rev, TIMM23B, APBB1, PIN1, WBP4, TCERG1, GAS7, PRPF40A, PARK2, UBD, CD81, PAN2, RNF43, WHSC1, VCAM1, SMAD5, ITGA4, FN1, CSNK2A1, BTK, DNA
Protein Size: 707

Poids moléculaire: 78 kDa

ID gène: 6421

NCBI Accession: NM_005066, NP_005057

UniProt: P23246