SRSF1 anticorps (C-Term)

N° du produit ABIN2779013

Détail du produit anti-SRSF1 anticorps

Antigène: SRSF1 (serine/arginine-Rich Splicing Factor 1 (SRSF1))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Poisson zèbre (Danio rerio), Chien, Boeuf (Vache), Cobaye, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SRSF1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: EFVRKEDMTY AVRKLDNTKF RSHEGETAYI RVKVDGPRSP SYGRSRSRSR

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against SFRS1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human SFRS1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 248 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-SRSF1 (ABIN2779013)

Li, Xia, Huang, Chen, Su, Li, Wang, Ding, Shao: "A strategy to rapidly identify the functional targets of microRNAs by combining bioinformatics and mRNA cytoplasmic/nucleic ratios in culture cells." dans: FEBS letters, Vol. 584, Issue 14, pp. 3198-202, (2010) (PubMed).

Détails sur SRSF1

Antigène: SRSF1 (serine/arginine-Rich Splicing Factor 1 (SRSF1))

Autre désignation: SFRS1 (SRSF1 Produits)

Synonymes: anticorps ASF, anticorps SF2, anticorps SF2p33, anticorps SFRS1, anticorps SRp30a, anticorps 1110054N12Rik, anticorps 5730507C05Rik, anticorps 6330415C05Rik, anticorps AI482334, anticorps AW491331, anticorps Asf, anticorps Sf2, anticorps Sfrs1, anticorps DKFZp469K2419, anticorps sfrs1, anticorps sfrs1b, anticorps wu:fb80g05, anticorps zgc:111894, anticorps zgc:65898, anticorps zgc:76897, anticorps asf, anticorps sf2, anticorps sf2p33, anticorps srp30a, anticorps sfrs1a, anticorps sfrs1l, anticorps wu:fb52g10, anticorps wu:fb97g12, anticorps zgc:66146, anticorps serine and arginine rich splicing factor 1, anticorps serine/arginine-rich splicing factor 1, anticorps serine/arginine-rich splicing factor 1b, anticorps serine/arginine-rich splicing factor 1 L homeolog, anticorps serine/arginine-rich splicing factor 1a, anticorps SRSF1, anticorps Srsf1, anticorps srsf1b, anticorps srsf1.L, anticorps srsf1a

Sujet: SFRS1 is a member of the arginine/serine-rich splicing factor protein family, and functions in both constitutive and alternative pre-mRNA splicing. The protein binds to pre-mRNA transcripts and components of the spliceosome, and can either activate or repress splicing depending on the location of the pre-mRNA binding site. The protein's ability to activate splicing is regulated by phosphorylation and interactions with other splicing factor associated proteins. Multiple transcript variants encoding different isoforms have been found for this gene.Alternative mRNA splicing plays an important role in development and differentiation, many transcripts are spliced differently in distinct cell types and tissues. Both constitutive and alternative splicing occurs on spliceosomes, which are complex particles composed of small nuclear ribonucleoproteins (snRNPs) and non-snRNP proteins. The SR family of non-snRNP splicing factors is characterized by the presence of an RNA recognition motif and a serine- and arginine-rich (SR) domain. SR proteins are required at early stages of spliceosome assembly, have distinct but overlapping specificities for different pre-mRNAs, and can alter splice site choice, suggesting that they may be involved in the regulation of alternative splicing in vivo. Two of the SR proteins, ASF/SF2 (SFRS1) and SC35 (SFRS2, MIM 600813), have been extensively characterized.Alternative mRNA splicing plays an important role in development and differentiation, many transcripts are spliced differently in distinct cell types and tissues. Both constitutive and alternative splicing occurs on spliceosomes, which are complex particles composed of small nuclear ribonucleoproteins (snRNPs) and non-snRNP proteins. The SR family of non-snRNP splicing factors is characterized by the presence of an RNA recognition motif and a serine- and arginine-rich (SR) domain. SR proteins are required at early stages of spliceosome assembly, have distinct but overlapping specificities for different pre-mRNAs, and can alter splice site choice, suggesting that they may be involved in the regulation of alternative splicing in vivo. Two of the SR proteins, ASF/SF2 (SFRS1) and SC35 (SFRS2, MIM 600813), have been extensively characterized (Bermingham et al., 1995).[supplied by OMIM].
Alias Symbols: ASF, SF2, SFRS1, SF2p33, SRp30a, SRSF1
Protein Interaction Partner: TRAF3IP2, HUWE1, SPRTN, STAU1, UBC, MDM2, ZBTB1, RNF2, EZH2, EED, SUZ12, PARK2, SRPK2, SRPK1, SRPK3, FBXO6, YWHAE, U2AF2, PAN2, MPG, CIR1, FN1, CDK6, HNRNPA0, RNPS1, SRSF10, NXF1, PRPF4, BCL10, U2AF1, SRSF4, MAGOH, SMURF1, EIF4A3, ESR1, ECT2, BRCA1, BARD1
Protein Size: 248

Poids moléculaire: 27 kDa

ID gène: 6426

NCBI Accession: NM_006924, NP_008855

UniProt: Q07955

Pathways: Ribonucleoprotein Complex Subunit Organization