Calreticulin anticorps (C-Term)
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- Antigène Voir toutes Calreticulin (CALR) Anticorps
- Calreticulin (CALR)
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Épitope
- C-Term
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Reactivité
- Humain, Souris, Rat, Chien, Cobaye, Lapin, Cheval, Poisson zèbre (Danio rerio), Saccharomyces cerevisiae, Chévre
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Calreticulin est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Séquence
- FGNETWGVTK AAEKQMKDKQ DEEQRLKEEE EDKKRKEEEE AEDKEDDEDK
- Homologie
- Dog: 100%, Goat: 86%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Yeast: 92%, Zebrafish: 79%
- Attributs du produit
- This is a rabbit polyclonal antibody against CALR. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the C terminal region of human CALR
- Top Product
- Discover our top product CALR Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 417 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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MAPRE1 as a plasma biomarker for early-stage colorectal cancer and adenomas." dans: Cancer prevention research (Philadelphia, Pa.), Vol. 8, Issue 11, pp. 1112-9, (2015) (PubMed).
: "
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MAPRE1 as a plasma biomarker for early-stage colorectal cancer and adenomas." dans: Cancer prevention research (Philadelphia, Pa.), Vol. 8, Issue 11, pp. 1112-9, (2015) (PubMed).
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- Antigène
- Calreticulin (CALR)
- Autre désignation
- CALR (CALR Produits)
- Synonymes
- anticorps CRT, anticorps RO, anticorps SSA, anticorps cC1qR, anticorps crc, anticorps crt, anticorps Calregulin, anticorps CG9429, anticorps Clr, anticorps Dmel\\CG9429, anticorps anon-EST:Liang-2.11, anticorps anon-EST:Liang-2.17, anticorps anon-EST:fe3D7, anticorps clone 2.11, anticorps clone 2.17, anticorps eth, anticorps potp, anticorps cc1qr, anticorps ssa, anticorps NV19007, anticorps CRP55, anticorps ERp60, anticorps HACBP, anticorps CHOT1, anticorps CHT1, anticorps CT1, anticorps AA589632, anticorps CRTR, anticorps Creat, anticorps CCDS1, anticorps calrl2, anticorps fc66d10, anticorps wu:fc66d10, anticorps wu:fj50c03, anticorps zgc:66153, anticorps calreticulin, anticorps calreticulin L homeolog, anticorps Calreticulin, anticorps putative calreticulin, anticorps solute carrier family 6 member 8, anticorps solute carrier family 6 (neurotransmitter transporter, creatine), member 8, anticorps CALR, anticorps calr.L, anticorps Crt, anticorps crt, anticorps CRT, anticorps Calr, anticorps calr, anticorps LMJF_31_2600, anticorps Crc, anticorps Slc6a8, anticorps SLC6A8, anticorps LOC8269812
- Sujet
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Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium.
Alias Symbols: RO, CRT, SSA, cC1qR
Protein Interaction Partner: HUWE1, UBC, LGR4, MDM2, RNF2, SUZ12, rev, AARSD1, THG1L, NSUN2, SH3GLB1, EEF2K, ARPC1A, ANP32B, ACTR2, ARPC1B, ARPC3, ARPC5, TPD52L2, SH3GL1, RPA3, RPA1, PRKACA, PFDN5, LPP, PARK2, UPF2, UBD, SOX2, PDIA3, CLN5, ITGA3, HLA-E, HLA-A, CALR, SLC27A2, env, MTN
Protein Size: 417 - Poids moléculaire
- 48 kDa
- ID gène
- 811
- NCBI Accession
- NM_004343, NP_004334
- UniProt
- P27797
- Pathways
- Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, ER-Nucleus Signaling, Unfolded Protein Response
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