RAD17 anticorps (C-Term)
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- Antigène Voir toutes RAD17 Anticorps
- RAD17
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Épitope
- C-Term
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Reactivité
- Humain, Souris, Rat, Chien, Boeuf (Vache), Porc
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp RAD17 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- PTQATVPETW SLPLSQNSAS ELPASQPQPF SAQGDMEENI IIEDYESDGT
- Homologie
- Cow: 83%, Dog: 75%, Human: 100%, Mouse: 75%, Pig: 83%, Rat: 75%
- Attributs du produit
- This is a rabbit polyclonal antibody against RAD17. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Protein A purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the C terminal region of human RAD17
- Top Product
- Discover our top product RAD17 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 584 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling." dans: The EMBO journal, Vol. 23, Issue 23, pp. 4660-9, (2004) (PubMed).
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Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling." dans: The EMBO journal, Vol. 23, Issue 23, pp. 4660-9, (2004) (PubMed).
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- Antigène
- RAD17
- Autre désignation
- RAD17 (RAD17 Produits)
- Synonymes
- anticorps zgc:91969, anticorps RAD17, anticorps K2A18.21, anticorps K2A18_21, anticorps RADIATION SENSITIVE 17, anticorps CCYC, anticorps HRAD17, anticorps R24L, anticorps RAD17SP, anticorps RAD24, anticorps 9430035O09Rik, anticorps MmRad24, anticorps RAD17 checkpoint clamp loader component, anticorps Rad17p, anticorps RADIATION SENSITIVE 17, anticorps RAD17, anticorps rad17, anticorps ATRAD17, anticorps Rad17
- Sujet
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RAD17 is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by ATR after the damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation.The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by ATR after the damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported.
Alias Symbols: CCYC, HRAD17, R24L, RAD17Sp, Rad24, RAD24, RAD17SP
Protein Interaction Partner: USP20, UBC, PRMT6, CBX7, CBX6, RAD9A, CDH1, ATR, RFC1, H2AFX, FOXO3, ATM, CLSPN, ALK, RAD9B, POLE, HUS1, RAD1, NHP2L1, MCM7, RFC4, RFC5, RFC3, RFC2, POLE4, POLE3, POLE2, PRKDC,
Protein Size: 584 - Poids moléculaire
- 66 kDa
- ID gène
- 5884
- NCBI Accession
- NM_133341, NP_579919
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