FAS anticorps (Middle Region)
-
- Antigène Voir toutes FAS Anticorps
- FAS (TNF Receptor Superfamily, Member 6 (FAS))
-
Épitope
- Middle Region
-
Reactivité
- Humain, Porc
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp FAS est non-conjugé
-
Application
- Western Blotting (WB)
- Séquence
- KKEAYDTLIK DLKKANLCTL AEKIQTIILK DITSDSENSN FRNEIQSLV
- Homologie
- Human: 100%, Pig: 80%
- Attributs du produit
- This is a rabbit polyclonal antibody against FAS. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the middle region of human FAS
- Top Product
- Discover our top product FAS Anticorps primaire
-
-
- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
-
Antigen size: 335 AA
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
- Antigène
- FAS (TNF Receptor Superfamily, Member 6 (FAS))
- Autre désignation
- FAS (FAS Produits)
- Synonymes
- anticorps ALPS1A, anticorps APO-1, anticorps APT1, anticorps CD95, anticorps FAS1, anticorps FASTM, anticorps TNFRSF6, anticorps AI196731, anticorps APO1, anticorps TNFR6, anticorps Tnfrsf6, anticorps lpr, anticorps Fas cell surface death receptor, anticorps Fas (TNF receptor superfamily member 6), anticorps FAS, anticorps Fas, anticorps fas
- Sujet
-
FAS is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.
Alias Symbols: ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6
Protein Interaction Partner: FADD, CAV1, FAS, APOA5, TMX1, UBQLN1, MBD4, TP63, TCAP, BAG6, UBC, HNRNPC, GADD45A, CCND3, ATP6V0B, SQSTM1, Ube2i, PRAM1, RARA, PML, DAXX, FASLG, TRADD, MAP3K5, BMX, Traf1, FAF1, FAF2, TRAF3, KRIT1, TNF, BRE, LRIF1, FEM1B, FBF1, FAIM2, CASP8AP2, C14orf1,
Protein Size: 335 - Poids moléculaire
- 36 kDa
- ID gène
- 355
- NCBI Accession
- NM_000043, NP_000034
- UniProt
- P25445
- Pathways
- Signalisation p53, Apoptose, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity
-