ASCL2 anticorps (Middle Region)

N° du produit ABIN2779425

Détail du produit anti-ASCL2 anticorps

Antigène: ASCL2 (Achaete-Scute Complex Homolog 2 (ASCL2))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Lapin, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ASCL2 est non-conjugé

Application: Western Blotting (WB)

Séquence: QALRQHVPHG GASKKLSKVE TLRSAVEYIR ALQRLLAEHD AVRNALAGGL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 92%, Rabbit: 77%, Rat: 100%, Zebrafish: 77%

Attributs du produit: This is a rabbit polyclonal antibody against ASCL2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human ASCL2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 193 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-ASCL2 (ABIN2779425)

Schwitalla, Fingerle, Cammareri, Nebelsiek, Göktuna, Ziegler, Canli, Heijmans, Huels, Moreaux, Rupec, Gerhard, Schmid, Barker, Clevers, Lang, Neumann, Kirchner, Taketo, van den Brink, Sansom, Arkan et al.: "Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. ..." dans: Cell, Vol. 152, Issue 1-2, pp. 25-38, (2013) (PubMed).

Détails sur ASCL2

Antigène: ASCL2 (Achaete-Scute Complex Homolog 2 (ASCL2))

Autre désignation: ASCL2 (ASCL2 Produits)

Synonymes: anticorps ASH2, anticorps HASH2, anticorps MASH2, anticorps bHLHa45, anticorps ASCL2, anticorps 2410083I15Rik, anticorps Mash2, anticorps achaete-scute family bHLH transcription factor 2, anticorps ASCL2, anticorps Ascl2

Sujet: AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1649 BC028140.1 1-1649 1650-1864 BC057801.1 1286-1500
Alias Symbols: ASH2, HASH2, MASH2, bHLHa45
Protein Interaction Partner: EP300, APEX1, CALM3, CALM1, HCFC1, TUBB, KMT2C, NCOA6, TUBA4A, RBBP5,
Protein Size: 193

Poids moléculaire: 20 kDa

ID gène: 430

NCBI Accession: NM_005170, NP_005161

UniProt: Q99929

Pathways: Stem Cell Maintenance