E2F6 anticorps (Middle Region)

N° du produit ABIN2779510

Détail du produit anti-E2F6 anticorps

Antigène: E2F6 (E2F Transcription Factor 6 (E2F6))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Porc, Boeuf (Vache), Chien, Cobaye, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp E2F6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: HEQIVIAVKA PAETRLDVPA PREDSITVHI RSTNGPIDVY LCEVEQGQTS

Homologie: Cow: 92%, Dog: 100%, Guinea Pig: 85%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against E2F6. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human E2F6

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 129 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-E2F6 (ABIN2779510)

Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: "Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France." dans: Diagnostic microbiology and infectious disease, Vol. 55, Issue 1, pp. 55-8, (2006) (PubMed).

Détails sur E2F6

Antigène: E2F6 (E2F Transcription Factor 6 (E2F6))

Autre désignation: E2F6 (E2F6 Produits)

Synonymes: anticorps E2F-6, anticorps AI462434, anticorps E2F6b, anticorps EMA, anticorps E2F transcription factor 6, anticorps E2F6, anticorps E2f6

Sujet: E2F6 is a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max. Multiple transcript variants encoding several different isoforms have been found for this gene.
Protein Interaction Partner: TFDP2, TFDP1, KRTAP10-7, LYN, ARAF, APP, PCGF6, RYBP, YAF2, RNF2, SMARCAD1, UBC, L3MBTL2, EZH2, Epc1, EED, KMT2D, KMT2A, RING1, E2F1, BMI1, ZMYND8, ZMYND11, KDM5C, EZH1, CBX3, E2F6,
Protein Size: 129

Poids moléculaire: 14 kDa

ID gène: 1876

NCBI Accession: NM_212540, NP_997705

UniProt: Q6Q9Z5