EPAS1 anticorps (Middle Region)
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- Antigène Voir toutes EPAS1 Anticorps
- EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))
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Épitope
- Middle Region
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Reactivité
- Humain, Souris, Rat, Cheval, Boeuf (Vache), Cobaye, Lapin, Chien, Poisson zèbre (Danio rerio)
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp EPAS1 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- ESLFKPHLMA MNSIFDSSGK GAVSEKSNFL FTKLKEEPEE LAQLAPTPGD
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%
- Attributs du produit
- This is a rabbit polyclonal antibody against EPAS1. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the middle region of human EPAS1
- Top Product
- Discover our top product EPAS1 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 870 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))
- Autre désignation
- EPAS1 (EPAS1 Produits)
- Synonymes
- anticorps EPAS1, anticorps ECYT4, anticorps HIF2A, anticorps HLF, anticorps MOP2, anticorps PASD2, anticorps bHLHe73, anticorps HIF-2alpha, anticorps HRF, anticorps Hif2a, anticorps bhlhe73, anticorps ecyt4, anticorps hif2, anticorps hif2a, anticorps hif2alpha, anticorps hlf, anticorps mop2, anticorps pasd2, anticorps EPAS, anticorps EPAS-1, anticorps endothelial PAS domain protein 1, anticorps endothelial PAS domain protein 1 L homeolog, anticorps EPAS1, anticorps epas1, anticorps Epas1, anticorps epas1.L
- Sujet
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EPAS1 is a transcription factor involved in the induction of oxygen regulated genes. EPAS1 binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. EPAS1 regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. EPAS1 may also play a role in the formation of the endothelium that gives rise to the blood brain barrier. EPAS1 is a potent activator of the Tie-2 tyrosine kinase expression. The activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction of EPAS1 with redox regulatory protein APEX seems to activate CTAD.
Alias Symbols: HIF2A, HLF, MOP2, PASD2, ECYT4, bHLHe73
Protein Interaction Partner: MAP1LC3A, SQSTM1, LAMP1, BATF2, BATF3, BATF, DDIT3, DBP, NDN, JUN, EPAS1, NPM1, BBS4, BBS2, BBS1, Arnt, VHL, STAT5A, SMAD3, EWSR1, MED11, MED8, EGLN3, PSMD1, PSMB1, MED1, PHB, MITF, HIF1A, EP300, EMD, CTNNB1, CREBBP, EGLN2, DPY30, MED10, MED25, ARID1B, WR
Protein Size: 870 - Poids moléculaire
- 90 kDa
- ID gène
- 2034
- NCBI Accession
- NM_001430, NP_001421
- UniProt
- Q99814
- Pathways
- Signaling Events mediated by VEGFR1 and VEGFR2, L'effet Warburg
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