ETV4 anticorps (Middle Region)
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- Antigène Voir toutes ETV4 Anticorps
- ETV4 (Ets Variant 4 (ETV4))
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Épitope
- Middle Region
- Reactivité
- Humain, Souris, Rat, Chien, Porc, Boeuf (Vache), Lapin, Cheval
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp ETV4 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- HSSVFQQPLD ICHSFTSQGG GREPLPAPYQ HQLSEPCPPY PQQSFKQEYH
- Homologie
- Cow: 100%, Dog: 86%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against ETV4. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the middle region of human ETV4
- Top Product
- Discover our top product ETV4 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 484 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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An Interaction with Ewing's Sarcoma Breakpoint Protein EWS Defines a Specific Oncogenic Mechanism of ETS Factors Rearranged in Prostate Cancer." dans: Cell reports, Vol. 17, Issue 5, pp. 1289-1301, (2016) (PubMed).
: "Inactivation of Capicua drives cancer metastasis." dans: Nature genetics, Vol. 49, Issue 1, pp. 87-96, (2016) (PubMed).
: "Prostate cancer ETS rearrangements switch a cell migration gene expression program from RAS/ERK to PI3K/AKT regulation." dans: Molecular cancer, Vol. 13, pp. 61, (2014) (PubMed).
: "The ETS gene ETV4 is required for anchorage-independent growth and a cell proliferation gene expression program in PC3 prostate cells." dans: Genes & cancer, Vol. 1, Issue 10, pp. 1044-1052, (2011) (PubMed).
: "Oncogenic ETS proteins mimic activated RAS/MAPK signaling in prostate cells." dans: Genes & development, Vol. 25, Issue 20, pp. 2147-57, (2011) (PubMed).
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An Interaction with Ewing's Sarcoma Breakpoint Protein EWS Defines a Specific Oncogenic Mechanism of ETS Factors Rearranged in Prostate Cancer." dans: Cell reports, Vol. 17, Issue 5, pp. 1289-1301, (2016) (PubMed).
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- Antigène
- ETV4 (Ets Variant 4 (ETV4))
- Autre désignation
- ETV4 (ETV4 Produits)
- Synonymes
- anticorps E1A-F, anticorps E1AF, anticorps PEA3, anticorps PEAS3, anticorps Pea3, anticorps AW414408, anticorps Pea-3, anticorps pea3, anticorps ETS variant 4, anticorps ets variant 4, anticorps ETV4, anticorps Etv4, anticorps etv4
- Sujet
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The protein encoded by the ETV4 gene is known to play a role in ovarian and breast malignancies as well as in the early stage of colorectal carcinogenesis.
Alias Symbols: E1A-F, E1AF, PEA3, PEAS3
Protein Interaction Partner: STK11, RFWD2, TP63, ATXN1, HTT, APP, UBC, SMAD2, SUMO2, SUMO1, SAE1, UBA2, HOXD4, EP300, SRF,
Protein Size: 484 - Poids moléculaire
- 54 kDa
- ID gène
- 2118
- NCBI Accession
- NM_001986, NP_001977
- UniProt
- P43268
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