ASCL1 anticorps (N-Term)

N° du produit ABIN2779585

Détail du produit anti-ASCL1 anticorps

Antigène: ASCL1 (Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Cobaye, Chien, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ASCL1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: QSAQQQQQQQ QQQQQAPQLR PAADGQPSGG GHKSAPKQVK RQRSSSPELM

Homologie: Cow: 100%, Dog: 92%, Guinea Pig: 100%, Human: 100%, Mouse: 92%, Rabbit: 92%, Rat: 92%

Attributs du produit: This is a rabbit polyclonal antibody against ASCL1. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human ASCL1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 236 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-ASCL1 (ABIN2779585)

Suozzi, Malatesta, Zancanaro: "Subcellular distribution of key enzymes of lipid metabolism during the euthermia-hibernation-arousal cycle." dans: Journal of anatomy, Vol. 214, Issue 6, pp. 956-62, (2009) (PubMed).

Vias, Massie, East, Scott, Warren, Zhou, Nikitin, Neal, Mills: "Pro-neural transcription factors as cancer markers." dans: BMC medical genomics, Vol. 1, pp. 17, (2008) (PubMed).

Détails sur ASCL1

Antigène: ASCL1 (Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1))

Autre désignation: ASCL1 (ASCL1 Produits)

Synonymes: anticorps ASH1, anticorps HASH1, anticorps MASH1, anticorps bHLHa46, anticorps AI225900, anticorps Mash1, anticorps ASCL1, anticorps Zash-1a, anticorps ash, anticorps asha, anticorps id:ibd5085, anticorps im:7138587, anticorps si:dkey-264k15.2, anticorps zash1a, anticorps zasha, anticorps Xash1, anticorps ascl1-A, anticorps Zash-1b, anticorps ashb, anticorps zashb, anticorps achaete-scute family bHLH transcription factor 1, anticorps achaete-scute family bHLH transcription factor 1a, anticorps achaete-scute family bHLH transcription factor 1 L homeolog, anticorps achaete-scute complex homolog 1, anticorps achaete-scute family bHLH transcription factor 1b, anticorps ASCL1, anticorps Ascl1, anticorps ascl1a, anticorps ascl1.L, anticorps LOC100220505, anticorps ascl1b

Sujet: ASCL1 encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. It is highly expressed in medullary thyroid cancer and small cell lung cancer and may be a useful marker for these cancers.
Alias Symbols: ASH1, HASH1, MASH1, bHLHa46
Protein Interaction Partner: MEF2D, MEF2C, MEF2A, NEUROG2, UBQLN1, EP300, TCF4, BMP2, ASCL1,
Protein Size: 236

Poids moléculaire: 25 kDa

ID gène: 429

NCBI Accession: NM_004316, NP_004307

UniProt: P50553

Pathways: Dopaminergic Neurogenesis