HES1 anticorps (N-Term)
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- Antigène Voir toutes HES1 Anticorps
- HES1 (Hes Family bHLH Transcription Factor 1 (HES1))
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Épitope
- N-Term
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Reactivité
- Humain, Souris, Rat, Boeuf (Vache), Lapin, Poisson zèbre (Danio rerio), Cobaye, Cheval
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp HES1 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
- Séquence
- NTTPDKPKTA SEHRKSSKPI MEKRRRARIN ESLSQLKTLI LDALKKDSSR
- Homologie
- Cow: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against HES1. It was validated on Western Blot and immunohistochemistry.
- Purification
- Protein A purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the N terminal region of human HES1
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 280 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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Inhibition of breast cancer cell survival by Xanthohumol via modulation of the Notch signaling pathway in vivo and in vitro." dans: Oncology letters, Vol. 15, Issue 1, pp. 908-916, (2018) (PubMed).
: "Targeting Notch Signaling and Autophagy Increases Cytotoxicity in Glioblastoma Neurospheres." dans: Brain pathology (Zurich, Switzerland), Vol. 26, Issue 6, pp. 713-723, (2015) (PubMed).
: "Rac1 contributes to cerebral ischemia reperfusion-induced injury in mice by regulation of Notch2." dans: Neuroscience, Vol. 306, pp. 100-14, (2015) (PubMed).
: "Atractylenolide I-mediated Notch pathway inhibition attenuates gastric cancer stem cell traits." dans: Biochemical and biophysical research communications, Vol. 450, Issue 1, pp. 353-9, (2014) (PubMed).
: "Hypoxia promotes uveal melanoma invasion through enhanced Notch and MAPK activation." dans: PLoS ONE, Vol. 9, Issue 8, pp. e105372, (2014) (PubMed).
: "Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling." dans: The Journal of experimental medicine, Vol. 210, Issue 1, pp. 71-84, (2013) (PubMed).
: "Overexpression of hCLP46 enhances Notch activation and regulates cell proliferation in a cell type-dependent manner." dans: Cell proliferation, Vol. 46, Issue 3, pp. 254-62, (2013) (PubMed).
: "Notch signaling promotes growth and invasion in uveal melanoma." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 18, Issue 3, pp. 654-65, (2012) (PubMed).
: "hCLP46 regulates U937 cell proliferation via Notch signaling pathway." dans: Biochemical and biophysical research communications, Vol. 408, Issue 1, pp. 84-8, (2011) (PubMed).
: "Notch signalling is off and is uncoupled from HES1 expression in Ewing's sarcoma." dans: The Journal of pathology, Vol. 225, Issue 3, pp. 353-63, (2011) (PubMed).
: "The Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling: a potential mechanism of therapeutic resistance." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 16, Issue 24, pp. 6060-70, (2010) (PubMed).
: "Down-regulation of the notch pathway in human airway epithelium in association with smoking and chronic obstructive pulmonary disease." dans: American journal of respiratory and critical care medicine, Vol. 179, Issue 6, pp. 457-66, (2009) (PubMed).
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Inhibition of breast cancer cell survival by Xanthohumol via modulation of the Notch signaling pathway in vivo and in vitro." dans: Oncology letters, Vol. 15, Issue 1, pp. 908-916, (2018) (PubMed).
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- Antigène
- HES1 (Hes Family bHLH Transcription Factor 1 (HES1))
- Autre désignation
- HES1 (HES1 Produits)
- Sujet
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HES1 belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box.
Alias Symbols: HHL, HRY, HES-1, bHLHb39
Protein Interaction Partner: STAT3, JAK2, APH1A, LTBR, ASGR2, TLE1, ELAVL1, PARP1, UBC, NUDT3, HDAC6, YWHAB, PTK2, NR4A1, HMGCL, GAPDH, FHL1, CSNK1E, APCS, FANCE, FANCC, FANCA, FANCL, SPTAN1, HSP90AA1, HSPA4, FANCG, FANCF, HDAC1, RUNX2, HES6, ID4, ID1, SIRT1, UBQLN1, HEY2, ID2, ID3,
Protein Size: 280 - Poids moléculaire
- 30 kDa
- ID gène
- 3280
- NCBI Accession
- NM_005524, NP_005515
- UniProt
- Q14469
- Pathways
- Réparation de l'ADN
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