PITX2 anticorps (N-Term)
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- Antigène Voir toutes PITX2 Anticorps
- PITX2 (Paired-Like Homeodomain 2 (PITX2))
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Épitope
- N-Term
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Reactivité
- Humain, Souris, Cheval
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp PITX2 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- EFTDSPESRK EAASSKFFPR QHPGANEKDK SQQGKNEDVG AEDPSKKKRQ
- Homologie
- Horse: 86%, Human: 100%, Mouse: 93%
- Attributs du produit
- This is a rabbit polyclonal antibody against PITX2. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the N terminal region of human PITX2
- Top Product
- Discover our top product PITX2 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 317 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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PITX2 gain-of-function induced defects in mouse forelimb development." dans: BMC developmental biology, Vol. 8, pp. 25, (2008) (PubMed).
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PITX2 gain-of-function induced defects in mouse forelimb development." dans: BMC developmental biology, Vol. 8, pp. 25, (2008) (PubMed).
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- Antigène
- PITX2 (Paired-Like Homeodomain 2 (PITX2))
- Autre désignation
- PITX2 (PITX2 Produits)
- Synonymes
- anticorps ARP1, anticorps Brx1, anticorps IDG2, anticorps IGDS, anticorps IGDS2, anticorps IHG2, anticorps IRID2, anticorps Otlx2, anticorps PTX2, anticorps RGS, anticorps RIEG, anticorps RIEG1, anticorps RS, anticorps 9430085M16Rik, anticorps Brx1a, anticorps Brx1b, anticorps Munc30, anticorps Pitx2a, anticorps Pitx2b, anticorps Pitx2c, anticorps Pitx2cbeta, anticorps Ptx2, anticorps Rieg, anticorps pitx2a, anticorps pitx2c, anticorps zgc:110508, anticorps XPtx2b, anticorps xPtx2, anticorps xpitx2, anticorps arp1, anticorps brx1, anticorps idg2, anticorps igds, anticorps igds2, anticorps ihg2, anticorps irid2, anticorps otlx2, anticorps pitx2-A, anticorps ptx2, anticorps rgs, anticorps rieg, anticorps rieg1, anticorps pitx-2, anticorps pitx2, anticorps paired like homeodomain 2, anticorps paired-like homeodomain transcription factor 2, anticorps paired-like homeodomain 2, anticorps paired like homeodomain 2 S homeolog, anticorps paired like homeodomain 2 L homeolog, anticorps PITX2, anticorps Pitx2, anticorps pitx2, anticorps pitx2.S, anticorps pitx2.L
- Sujet
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The PITX2 gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. This protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. Mutations in PITX2 are associated with Axenfeld-Rieger syndrome (ARS), iridogoniodysgenesis syndrome (IGDS), and sporadic cases of Peters anomaly. This protein is involved in the development of the eye, tooth and abdominal organs. It also acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Alias Symbols: ARP1, Brx1, IDG2, IGDS, IGDS2, IHG2, IRID2, MGC111022, MGC20144, Otlx2, PTX2, RGS, RIEG, RIEG1, RS
Protein Interaction Partner: LEF1, Hoxa1, WDR5, SMAD3, HDAC1, CTNNB1, ZNHIT3, TRIM25, HERC5, PDLIM1, PITX2, PROP1, KAT5, Pou1f1, MSX2,
Protein Size: 317 - Poids moléculaire
- 35 kDa
- ID gène
- 5308
- NCBI Accession
- NM_153426, NP_700475
- UniProt
- Q99697
- Pathways
- Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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