FBXW7 anticorps (Middle Region)
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- Antigène Voir toutes FBXW7 Anticorps
- FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))
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Épitope
- Middle Region
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Reactivité
- Humain, Souris, Rat, Chien, Boeuf (Vache), Lapin, Cobaye, Cheval, Poisson zèbre (Danio rerio)
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp FBXW7 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Séquence
- GIDEPLHIKR RKIIKPGFIH SPWKSAYIRQ HRIDTNWRRG ELKSPKVLKG
- Homologie
- Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 93%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 93%
- Attributs du produit
- This is a rabbit polyclonal antibody against Fbxw7. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the middle region of mouse Fbxw7
- Top Product
- Discover our top product FBXW7 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 629 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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NF-κB1 inhibits c-Myc protein degradation through suppression of FBW7 expression." dans: Oncotarget, Vol. 5, Issue 2, pp. 493-505, (2014) (PubMed).
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NF-κB1 inhibits c-Myc protein degradation through suppression of FBW7 expression." dans: Oncotarget, Vol. 5, Issue 2, pp. 493-505, (2014) (PubMed).
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- Antigène
- FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))
- Autre désignation
- Fbxw7 (FBXW7 Produits)
- Synonymes
- anticorps cdc4, anticorps AGO, anticorps CDC4, anticorps FBW6, anticorps FBW7, anticorps FBX30, anticorps FBXO30, anticorps FBXW6, anticorps SEL-10, anticorps SEL10, anticorps hAgo, anticorps hCdc4, anticorps 1110001A17Rik, anticorps Cdc4, anticorps Fbw7, anticorps Fbwd6, anticorps Fbx30, anticorps Fbxo30, anticorps Fbxw6, anticorps F-box and WD repeat domain containing 7, anticorps F-box and WD-40 domain protein 7, anticorps Fbxw7, anticorps FBXW7, anticorps fbxw7
- Sujet
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Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.
Alias Symbols: 1110001A17Rik, AGO, Cdc4, Fbw7, Fbwd6, Fbx30, Fbxo30, Fbxw6, SEL-10
Protein Interaction Partner: Skp1a, CREB3L1, CREB3L2, Cul1, Prkcz, Prkce, Prkcd, Prkcb, Prkca, Pten, Mcl1, CEBPA, Pin1, MYB, Npm1, Jun,
Protein Size: 629 - Poids moléculaire
- 70 kDa
- ID gène
- 50754
- NCBI Accession
- NM_080428, NP_536353
- UniProt
- Q8VBV4
- Pathways
- Signalisation Notch, EGFR Signaling Pathway
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