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RCAN1 anticorps (Middle Region)

RCAN1 Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Cheval, Mouton, Lapin, Poisson zèbre (Danio rerio) WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2780590
  • Antigène Voir toutes RCAN1 Anticorps
    RCAN1 (Regulator of Calcineurin 1 (RCAN1))
    Épitope
    • 15
    • 11
    • 7
    • 7
    • 6
    • 5
    • 5
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivité
    • 78
    • 19
    • 17
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Cheval, Mouton, Lapin, Poisson zèbre (Danio rerio)
    Hôte
    • 73
    • 5
    • 1
    Lapin
    Clonalité
    • 77
    • 2
    Polyclonal
    Conjugué
    • 38
    • 7
    • 5
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp RCAN1 est non-conjugé
    Application
    • 62
    • 38
    • 13
    • 13
    • 9
    • 8
    • 7
    • 3
    • 3
    • 2
    Western Blotting (WB)
    Séquence
    PVINYDLLYA ISKLGPGEKY ELHAATDTTP SVVVHVCESD QEKEEEEEME
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Sheep: 100%, Zebrafish: 79%
    Attributs du produit
    This is a rabbit polyclonal antibody against RCAN1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the middle region of human RCAN1
    Top Product
    Discover our top product RCAN1 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 252 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Voronov, Ochotny, Jaumouillé, Owen, Manolson, Aubin: "The R740S mutation in the V-ATPase a3 subunit increases lysosomal pH, impairs NFATc1 translocation, and decreases in vitro osteoclastogenesis." dans: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 28, Issue 1, pp. 108-18, (2012) (PubMed).

  • Antigène
    RCAN1 (Regulator of Calcineurin 1 (RCAN1))
    Autre désignation
    RCAN1 (RCAN1 Produits)
    Synonymes
    anticorps ADAPT78, anticorps CSP1, anticorps DSC1, anticorps DSCR1, anticorps MCIP1, anticorps RCN1, anticorps RCAN1, anticorps 2410048A02Rik, anticorps AA408855, anticorps AI429645, anticorps AL024459, anticorps AV028423, anticorps Adapt78, anticorps CALP1L, anticorps Dscr1, anticorps Mcip1, anticorps dscr1, anticorps rcan1, anticorps wu:fr92c05, anticorps adapt78, anticorps csp1, anticorps dsc1, anticorps mcip1, anticorps MGC53636, anticorps rcn1, anticorps MGC69428, anticorps regulator of calcineurin 1, anticorps regulator of calcineurin 1b, anticorps regulator of calcineurin 1 L homeolog, anticorps Down syndrome critical region gene 1, anticorps RCAN1, anticorps Rcan1, anticorps rcan1b, anticorps rcan1.L, anticorps dscr1, anticorps rcan1
    Sujet
    RCAN1 interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease.The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene.
    Alias Symbols: ADAPT78, CSP1, DSC1, DSCR1, MCIP1, RCN1
    Protein Interaction Partner: UBC, PPP3CA, NEDD8, APP, FBXW11, BTRC, FBXW4, TOLLIP, TRAF6, IRAK1, HSP90AA1, STAT2, GSK3B, MAP3K3, MAPK3, UXT,
    Protein Size: 252
    Poids moléculaire
    28 kDa
    ID gène
    1827
    NCBI Accession
    NM_004414, NP_004405
    UniProt
    P53805
    Pathways
    Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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