HMGN1 anticorps (Middle Region)

N° du produit ABIN2780630

Détail du produit anti-HMGN1 anticorps

Antigène: HMGN1 (High Mobility Group Nucleosome Binding Domain 1 (HMGN1))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Porc, Chien, Cheval, Lapin, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HMGN1 est non-conjugé

Application: Western Blotting (WB)

Séquence: QTKGKRGAKG KQAEVANQET KEDLPAENGE TKTEESPASD EAGEKEAKSD

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 79%, Pig: 100%, Rabbit: 93%, Rat: 79%

Attributs du produit: This is a rabbit polyclonal antibody against HMGN1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human HMGN1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 100 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-HMGN1 (ABIN2780630)

Lane, Chapuy, Lin, Tivey, Li, Townsend, van Bodegom, Day, Wu, Liu, Yoda, Alexe, Schinzel, Sullivan, Malinge, Taylor, Stegmaier, Jaffe, Bustin, te Kronnie, Izraeli, Harris, Stevenson, Neuberg et al.: "Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation. ..." dans: Nature genetics, Vol. 46, Issue 6, pp. 618-23, (2014) (PubMed).

Détails sur HMGN1

Antigène: HMGN1 (High Mobility Group Nucleosome Binding Domain 1 (HMGN1))

Autre désignation: HMGN1 (HMGN1 Produits)

Synonymes: anticorps HMG14, anticorps hmg14, anticorps hmgn1, anticorps hmgn1b, anticorps HMG-14, anticorps Hmg14, anticorps high mobility group nucleosome binding domain 1, anticorps high mobility group nucleosome binding domain 1 S homeolog, anticorps high mobility group nucleosomal binding domain 1, anticorps non-histone chromosomal protein HMG-14, anticorps HMGN1, anticorps hmgn1.S, anticorps hmgn1, anticorps Hmgn1, anticorps LOC785479

Sujet: Chromosomal protein HMG14 (HMGN1) and its close analog HMG17 (MIM 163910) bind to the inner side of the nucleosomal DNA, potentially altering the interaction between the DNA and the histone octamer. The 2 proteins may be involved in the process that maintains transcribable genes in a unique chromatin conformation. Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.Chromosomal protein HMG14 and its close analog HMG17 (MIM 163910) bind to the inner side of the nucleosomal DNA, potentially altering the interaction between the DNA and the histone octamer. The 2 proteins may be involved in the process that maintains transcribable genes in a unique chromatin conformation. Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: FLJ27265, FLJ31471, HMG14, MGC104230, MGC117425
Protein Interaction Partner: UBC, RPS6KA3, PRKCA, PRKACG, SLC38A3, PPP1CC, LIG4, PPIP5K1, TERF2, SPP1, POLR2A, ERCC8, HDGF, EP300, BTG2, ERCC6, NFE2, RPS6KA5, RPS6KA4, PRKACA, YWHAZ, HMGN1, HMGN2, IRF2,
Protein Size: 100

Poids moléculaire: 11 kDa

ID gène: 3150

NCBI Accession: NM_004965, NP_004956

UniProt: Q6NSG7

Pathways: Chromatin Binding