MECP2 anticorps (Middle Region)
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- Antigène Voir toutes MECP2 Anticorps
- MECP2 (Methyl CpG Binding Protein 2 (MECP2))
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Épitope
- Middle Region
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Reactivité
- Humain, Souris, Rat, Cheval, Chien, Boeuf (Vache), Cobaye, Lapin, Poisson zèbre (Danio rerio)
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp MECP2 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- EPAKTQPAVA TAATAAEKYK HRGEGERKDI VSSSMPRPNR EEPVDSRTPV
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 75%
- Attributs du produit
- This is a rabbit polyclonal antibody against MECP2. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the middle region of human MECP2
- Top Product
- Discover our top product MECP2 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 486 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- MECP2 (Methyl CpG Binding Protein 2 (MECP2))
- Autre désignation
- MECP2 (MECP2 Produits)
- Synonymes
- anticorps AUTSX3, anticorps MRX16, anticorps MRX79, anticorps MRXS13, anticorps MRXSL, anticorps PPMX, anticorps RS, anticorps RTS, anticorps RTT, anticorps 1500041B07Rik, anticorps BB130002, anticorps D630021H01Rik, anticorps Mbd5, anticorps WBP10, anticorps wu:fk96a04, anticorps zgc:111857, anticorps methyl-CpG binding protein 2, anticorps methyl CpG binding protein 2, anticorps methyl-CpG binding protein 2 S homeolog, anticorps MECP2, anticorps Mecp2, anticorps mecp2, anticorps mecp2.S
- Sujet
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Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.
Alias Symbols: AUTSX3, DKFZp686A24160, MRX16, MRX79, MRXS13, MRXSL, PPMX, RTS, RTT, RS
Protein Interaction Partner: UBC, HECW2, Hipk2, SOX18, WHSC1, HPDL, XPC, CAT, HIST2H3C, HIST1H4F, HIST2H2BE, HIST2H2AC, CBX3, CBX1, SMC3, YBX1, SIN3A, CBX5, ELAVL1, SUMO2, PPARG, YY1, TERF2, SMARCA2, SOX2, SP1, SP3, LOC407840, CDKL5, PRPF40A, SMARCB1, NCOR1, SKI, HMGB1, SPI1, LBR, RB
Protein Size: 486 - Poids moléculaire
- 52 kDa
- ID gène
- 4204
- NCBI Accession
- NM_004992, NP_004983
- UniProt
- P51608
- Pathways
- Inositol Metabolic Process, Chromatin Binding, Synaptic Membrane
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