XBP1 anticorps (C-Term)
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- Antigène Voir toutes XBP1 Anticorps
- XBP1 (X-Box Binding Protein 1 (XBP1))
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Épitope
- C-Term
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Reactivité
- Humain, Souris, Rat, Boeuf (Vache), Lapin, Porc, Cheval
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp XBP1 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- LISCWAFWTT WTQSCSSNAL PQSLPAWRSS QRSTQKDPVP YQPPFLCQWG
- Homologie
- Cow: 79%, Horse: 85%, Human: 100%, Mouse: 91%, Pig: 86%, Rabbit: 86%, Rat: 91%
- Attributs du produit
- This is a rabbit polyclonal antibody against XBP1. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the C terminal region of human XBP1
- Top Product
- Discover our top product XBP1 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 261 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- XBP1 (X-Box Binding Protein 1 (XBP1))
- Autre désignation
- XBP1 (XBP1 Produits)
- Synonymes
- anticorps treb5, anticorps xXBP1, anticorps xbp2, anticorps XBP1P1, anticorps XBPP1, anticorps xbp1, anticorps TREB5, anticorps XBP-1, anticorps XBP2, anticorps D11Ertd39e, anticorps TREB-5, anticorps HTF, anticorps cb918, anticorps id:ibd1195, anticorps trebf, anticorps wu:fb02h05, anticorps wu:fb63f10, anticorps xbp1a, anticorps xbp1b, anticorps X-box binding protein 1, anticorps X-box binding protein 1 L homeolog, anticorps xbp1, anticorps XBP1, anticorps Xbp1, anticorps xbp1.L
- Sujet
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XBP1 is a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. XBP1 is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator.This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.
Alias Symbols: TREB5, XBP2
Protein Interaction Partner: DERL1, UBE2I, HM13, XBP1, CREBZF, ATF6, ATF6B, UBC, SUMO2, PSMA8, PSMA6, PSMA5, ZNF440, PCBD2, ZNF580, TRIP4, H1FX, FUBP3, NR0B2, SSX4, SRSF1, RBL2, HDGF, H1F0, GLI1, IRE1, FOS, ESR1, FOXA1, POLR2A,
Protein Size: 261 - Poids moléculaire
- 29 kDa
- ID gène
- 7494
- NCBI Accession
- NM_005080, NP_005071
- UniProt
- P17861
- Pathways
- ER-Nucleus Signaling, Unfolded Protein Response
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