ETS2 anticorps (Middle Region)

N° du produit ABIN2780665

Détail du produit anti-ETS2 anticorps

Antigène: ETS2 (V-Ets Erythroblastosis Virus E26 Oncogene Homolog 2 (ETS2))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Chien, Cheval, Boeuf (Vache), Cobaye, Lapin, Mouton, Chévre, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ETS2 est non-conjugé

Application: Western Blotting (WB)

Séquence: DPDEVARRWG KRKNKPKMNY EKLSRGLRYY YDKNIIHKTS GKRYVYRFVC

Homologie: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against ETS2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human ETS2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 469 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur ETS2

Antigène: ETS2 (V-Ets Erythroblastosis Virus E26 Oncogene Homolog 2 (ETS2))

Autre désignation: ETS2 (ETS2 Produits)

Synonymes: anticorps 0123/09, anticorps 0608/07, anticorps 0998/12, anticorps 3520, anticorps CG17077, anticorps CG8705, anticorps D-Ets-2, anticorps D-ets-2, anticorps DMPOINT1A, anticorps Dmel\\CG17077, anticorps E(E2F)3D, anticorps EK3-2, anticorps ETS2, anticorps EY3-1, anticorps Ets, anticorps Ets2, anticorps Ets58AB, anticorps Ets94F, anticorps PNT-P1, anticorps PNTP1, anticorps PNTP2, anticorps POINT, anticorps Pnt, anticorps Pnt-P1, anticorps PntP1, anticorps PntP2, anticorps Pointed-P1, anticorps ets94F, anticorps l(3)07825, anticorps l(3)j1B7, anticorps l(3)s118306, anticorps png, anticorps pnt-P1, anticorps pnt-P2, anticorps pntP2, anticorps pntegfr, anticorps pointed-RC, anticorps ptd, anticorps zgc:92106, anticorps wu:fe02h08, anticorps wu:fk74c05, anticorps AU022856, anticorps Ets-2, anticorps ETS2IT1, anticorps c-ets-2, anticorps pointed, anticorps v-ets avian erythroblastosis virus E26 oncogene homolog 2, anticorps E26 avian leukemia oncogene 2, 3' domain, anticorps ETS proto-oncogene 2, transcription factor, anticorps pnt, anticorps ets2, anticorps Ets2, anticorps ETS2

Sujet: ETS2 contains an ETS DNA-binding domain and belongs to the ETS family. ETS2 is a target of protein kinase C and upregulates GM-CSF. Ets2 and its targets play essential roles in endothelial cell function. Coexpression of Ets-2 and SRC-1 significantly associated with the rate of recurrence and HER expression in breast cancer. Overexpression of ETS2 is associated with human esophageal squamous cell carcinoma. ETS transcriptions factors, such as ETS2, regulate numerous genes and are involved in stem cell development, cell senescence and death, and tumorigenesis. The conserved ETS domain within these proteins is a winged helix-turn-helix DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T of target genes (Dwyer et al., 2007 [PubMed 17986575]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ETS2IT1
Protein Interaction Partner: UBC, RFWD2, TWIST1, POU5F1, TWIST2, ZFYVE9, SRA1, XPO1, TP53, SUMO2, EP300, CREBBP, NCOR1, NCOA3, SRC, ZMYND11, TDP2, STAT5B, CDK10, SMARCA4, JUN, ERG, ETS2, ETS1, NR3C1, GATA3, FOS, SPI1, BRCA1,
Protein Size: 469

Poids moléculaire: 53 kDa

ID gène: 2114

NCBI Accession: NM_005239, NP_005230

UniProt: P15036

Pathways: EGFR Signaling Pathway, Myometrial Relaxation and Contraction