REST anticorps (Middle Region)
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- Antigène Voir toutes REST Anticorps
- REST (RE1-Silencing Transcription Factor (REST))
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Épitope
- Middle Region
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Reactivité
- Humain, Rat, Souris, Chien, Cobaye, Cheval, Lapin, Boeuf (Vache)
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp REST est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- ANMGMALTND MYDLHELSKA ELAAPQLIML ANVALTGEAS GSCCDYLVGE
- Homologie
- Cow: 86%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 92%, Rabbit: 100%, Rat: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against Rest. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product REST Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 1082 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- REST (RE1-Silencing Transcription Factor (REST))
- Autre désignation
- Rest (REST Produits)
- Synonymes
- anticorps NRSF, anticorps XBR, anticorps 2610008J04Rik, anticorps AA407358, anticorps xbr, anticorps nrsf, anticorps rest, anticorps resta, anticorps REST, anticorps RE1 silencing transcription factor, anticorps RE1-silencing transcription factor, anticorps RE1-silencing transcription factor S homeolog, anticorps REST, anticorps Rest, anticorps rest.S, anticorps rest, anticorps LOC615792
- Sujet
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Rest is a transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Rest restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Rest mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.
Alias Symbols: 2610008J04Rik, AA407358, MGC150099, NRSF
Protein Interaction Partner: L3mbtl2, Htt, Nanog, Sp3, Ewsr1, Nr0b1, Syt4, Calb1, Scn2a1, Bdnf, Ascl1,
Protein Size: 1082 - Poids moléculaire
- 118 kDa
- ID gène
- 19712
- NCBI Accession
- NM_011263, NP_035393
- UniProt
- Q8VIG1
- Pathways
- Negative Regulation of Hormone Secretion, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Chromatin Binding, Positive Regulation of Endopeptidase Activity
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