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HIC1 anticorps (Middle Region)

HIC1 Reactivité: Humain, Souris, Rat, Cobaye, Chien, Boeuf (Vache), Cheval WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2780783
  • Antigène Voir toutes HIC1 Anticorps
    HIC1 (Hypermethylated in Cancer 1 (HIC1))
    Épitope
    • 15
    • 9
    • 8
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivité
    • 30
    • 19
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    Humain, Souris, Rat, Cobaye, Chien, Boeuf (Vache), Cheval
    Hôte
    • 41
    • 4
    • 1
    Lapin
    Clonalité
    • 42
    • 4
    Polyclonal
    Conjugué
    • 19
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp HIC1 est non-conjugé
    Application
    • 42
    • 23
    • 13
    • 13
    • 3
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB)
    Séquence
    GETPIAVMGE FANLATSLNP LDPDKDEEEE EEEESEDELP QDISLAAGGE
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rat: 93%
    Attributs du produit
    This is a rabbit polyclonal antibody against HIC1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the middle region of human HIC1
    Top Product
    Discover our top product HIC1 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 714 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Stöcklein, Smardova, Macak, Katzenberger, Höller, Wessendorf, Hutter, Dreyling, Haralambieva, Mäder, Müller-Hermelink, Rosenwald, Ott, Kalla: "Detailed mapping of chromosome 17p deletions reveals HIC1 as a novel tumor suppressor gene candidate telomeric to TP53 in diffuse large B-cell lymphoma." dans: Oncogene, Vol. 27, Issue 18, pp. 2613-25, (2008) (PubMed).

  • Antigène
    HIC1 (Hypermethylated in Cancer 1 (HIC1))
    Autre désignation
    HIC1 (HIC1 Produits)
    Synonymes
    anticorps zfHIC1, anticorps HIC1, anticorps ZBTB29, anticorps ZNF901, anticorps hic-1, anticorps AA408311, anticorps HIC-1, anticorps hypermethylated in cancer 1, anticorps HIC ZBTB transcriptional repressor 1, anticorps hic1, anticorps HIC1, anticorps Hic1
    Sujet
    HIC1 is a transcriptional repressor. HIC1 may act as a tumor suppressor. HIC1 may be involved in development of head, face, limbs and ventral body wall. Defects in HIC1 may be a cause of the facial dysmorphism and additional birth defects (except for lissencephaly) seen in the contiguous gene disorder Miller-Dieker syndrome (MDS), like defective development of the nose, jaws, extremities, gastrointestinal tract, and kidney.
    Alias Symbols: ZBTB29, hic-1, ZNF901
    Protein Interaction Partner: PIAS4, PIAS3, PIAS2, SP1, STAT3, SIRT1, MTA1, UBE2I, SUMO2, HIC2, TCF4, CTBP2, CTBP1, EED, PHF1, EZH2, PHF19, SUZ12, UBC, MBD3, RBBP4, CHD3, SENP3, HDAC4, PIAS1, ARID1A, HIC1, HDAC1,
    Protein Size: 714
    Poids moléculaire
    74 kDa
    ID gène
    3090
    NCBI Accession
    NM_006497, NP_006488
    UniProt
    Q14526
    Pathways
    Positive Regulation of Response to DNA Damage Stimulus
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