NCOA2 anticorps (N-Term)

N° du produit ABIN2780788

Détail du produit anti-NCOA2 anticorps

Antigène: NCOA2 (Nuclear Receptor Coactivator 2 (NCOA2))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Chien, Lapin, Boeuf (Vache), Cobaye, Cheval, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NCOA2 est non-conjugé

Application: Western Blotting (WB)

Séquence: MSGMGENTSD PSRAETRKRK ECPDQLGPSP KRNTEKRNRE QENKYIEELA

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against NCOA2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human NCOA2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1464 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-NCOA2 (ABIN2780788)

Strehl, Nebral, König, Harbott, Strobl, Ratei, Struski, Bielorai, Lessard, Zimmermann, Haas, Izraeli: "ETV6-NCOA2: a novel fusion gene in acute leukemia associated with coexpression of T-lymphoid and myeloid markers and frequent NOTCH1 mutations." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, Issue 4, pp. 977-83, (2008) (PubMed).

Détails sur NCOA2

Antigène: NCOA2 (Nuclear Receptor Coactivator 2 (NCOA2))

Autre désignation: NCOA2 (NCOA2 Produits)

Synonymes: anticorps GRIP1, anticorps KAT13C, anticorps NCoA-2, anticorps SRC2, anticorps TIF2, anticorps bHLHe75, anticorps 9530095N19, anticorps D1Ertd433e, anticorps GRIP-1, anticorps Grip1, anticorps SRC-2, anticorps TIF-2, anticorps tif2, anticorps wu:fc41a10, anticorps wu:fe26a11, anticorps Tif2, anticorps NCOA2, anticorps XTIF2, anticorps bhlhe75, anticorps grip1, anticorps kat13c, anticorps src2, anticorps ncoa2-A, anticorps nuclear receptor coactivator 2, anticorps nuclear receptor coactivator 2 S homeolog, anticorps NCOA2, anticorps Ncoa2, anticorps ncoa2, anticorps LOC100089041, anticorps ncoa2.S

Sujet: NCOA2 is the transcriptional coactivator for steroid receptors and nuclear receptors. NCOA2 is the coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). NCOA2 is required with NCOA1 to control energy balance
Alias Symbols: GRIP1, KAT13C, MGC138808, NCoA-2, TIF2, SRC2, bHLHe75
Protein Interaction Partner: VDR, PSMB9, PPARG, ESR1, PML, UBC, TP53, TAF9, Pias3, tat, THRB, NR3C1, EP300, NR1I2, RXRA, RARA, CREBBP, AHR, KANK2, MAGEA11, NCOA1, HHV8GK18_gp81, ESR2, PGR, SUMO2, CAD, ATR, HSPA2, CC2D1A, UBR5, TBK1, WDHD1, USO1, STAT6, NCOA3, THRA, CDK4, CCND3, EID1,
Protein Size: 1464

Poids moléculaire: 159 kDa

ID gène: 10499

NCBI Accession: NM_006540, NP_006531

UniProt: Q15596

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Regulation of Lipid Metabolism by PPARalpha, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling