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PATZ1 anticorps (Middle Region)

ZNF278 Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Lapin, Cobaye, Cheval, Poisson zèbre (Danio rerio) WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2780923
  • Antigène Voir toutes PATZ1 (ZNF278) Anticorps
    PATZ1 (ZNF278) (Zinc Finger Protein 278 (ZNF278))
    Épitope
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivité
    • 22
    • 15
    • 7
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Humain, Souris, Rat, Boeuf (Vache), Chien, Lapin, Cobaye, Cheval, Poisson zèbre (Danio rerio)
    Hôte
    • 18
    • 4
    Lapin
    Clonalité
    • 20
    • 2
    Polyclonal
    Conjugué
    • 15
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PATZ1 est non-conjugé
    Application
    • 15
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Séquence
    SFFRSKSYLN KHIQKVHVRA LGGPLGDLGP ALGSPFSPQQ NMSLLESFGF
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%
    Attributs du produit
    This is a rabbit polyclonal antibody against PATZ1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the middle region of human PATZ1
    Top Product
    Discover our top product ZNF278 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 687 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Antigène
    PATZ1 (ZNF278) (Zinc Finger Protein 278 (ZNF278))
    Autre désignation
    PATZ1 (ZNF278 Produits)
    Synonymes
    anticorps ZNF278, anticorps MAZR, anticorps PATZ, anticorps RIAZ, anticorps ZBTB19, anticorps ZSG, anticorps dJ400N23, anticorps 8430401L15Rik, anticorps AI447519, anticorps Mazr, anticorps Patz, anticorps Zfp278, anticorps Znf278, anticorps POZ/BTB and AT hook containing zinc finger 1, anticorps POZ/BTB and AT hook containing zinc finger 1 S homeolog, anticorps POZ (BTB) and AT hook containing zinc finger 1, anticorps POZ-, AT hook-, and zinc finger-containing protein 1, anticorps PATZ1, anticorps patz1.S, anticorps Patz1, anticorps LOC100153931
    Sujet
    PATZ1 contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1,22)(p36.1,q12).The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1,22)(p36.1,q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene.
    Alias Symbols: MAZR, PATZ, RIAZ, ZBTB19, ZNF278, ZSG, dJ400N23
    Protein Interaction Partner: TP53, SOX2, PRKAR1A, BCL6, BACH2, RNF4, BACH1, MITF, AR,
    Protein Size: 687
    Poids moléculaire
    74 kDa
    ID gène
    23598
    NCBI Accession
    NM_014323, NP_055138
    UniProt
    Q9HBE1
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