ZEB2 anticorps (Middle Region)

N° du produit ABIN2780948

Détail du produit anti-ZEB2 anticorps

Antigène: ZEB2 (Zinc Finger E-Box Binding Homeobox 2 (ZEB2))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Cheval, Cobaye, Porc, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZEB2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: LGRQDGDEEF EEEEEESENK SMDTDPETIR DEEETGDHSM DDSSEDGKME

Homologie: Cow: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%, Zebrafish: 79%

Attributs du produit: This is a rabbit polyclonal antibody against ZEB2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human ZEB2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1214 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-ZEB2 (ABIN2780948)

Yasumi, Inoue, Maruhashi, Kamachi, Higashi, Kondoh, Uchikawa: "Regulation of trunk neural crest delamination by δEF1 and Sip1 in the chicken embryo." dans: Development, growth & differentiation, Vol. 58, Issue 2, pp. 205-14, (2016) (PubMed).

Guan, Liang, Xie, Li, Liu, Liu, Xiu, Li: "Down-regulation of miR-144 promotes thyroid cancer cell invasion by targeting ZEB1 and ZEB2." dans: Endocrine, Vol. 48, Issue 2, pp. 566-74, (2015) (PubMed).

Rogers, Saxena, Bronner: "Sip1 mediates an E-cadherin-to-N-cadherin switch during cranial neural crest EMT." dans: The Journal of cell biology, Vol. 203, Issue 5, pp. 835-47, (2013) (PubMed).

Détails sur ZEB2

Antigène: ZEB2 (Zinc Finger E-Box Binding Homeobox 2 (ZEB2))

Autre désignation: ZEB2 (ZEB2 Produits)

Synonymes: anticorps ZFHX1B, anticorps Zfhx1b, anticorps HSPC082, anticorps SIP-1, anticorps SIP1, anticorps SMADIP1, anticorps 9130203F04Rik, anticorps D130016B08Rik, anticorps Zfx1b, anticorps Zfxh1b, anticorps mKIAA0569, anticorps XSip1, anticorps sip1, anticorps zfhx1b, anticorps si:dkey-52o2.2, anticorps sip1a, anticorps wu:fc92g08, anticorps sip1b, anticorps zinc finger E-box binding homeobox 2, anticorps zinc finger E-box binding homeobox 2 S homeolog, anticorps zinc finger homeobox protein, anticorps zinc finger E-box binding homeobox 2a, anticorps zinc finger E-box binding homeobox 2b, anticorps ZEB2, anticorps Zeb2, anticorps zeb2.S, anticorps zeb2, anticorps zeb2a, anticorps zeb2b

Sujet: The ZFHX1B gene is a member of the delta-EF1/Zfh1 family of 2-handed zinc finger/homeodomain proteins. ZFHX1B is strongly transcribed at an early stage in the developing peripheral and central nervous systems of both mice and humans, in all neuronal regions of the brains of 25-week human fetuses and adult mice, and in numerous nonneural tissues. The SMADIP1 gene (also known as SIP1) is a member of the delta-EF1 (ZEB1, MIM 189909)/Zfh1 family of 2-handed zinc finger/homeodomain proteins. SMADIP1 interacts with receptor-mediated, activated full-length SMADs (see MIM 605568) (Verschueren et al., 1999 [PubMed 10400677]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-58 AB056507.1 1-58 59-553 AL118674.1 57-551 554-5558 AB056507.1 553-5557 5559-5583 AI858477.1 1-25 c
Alias Symbols: KIAA0569, SIP-1, SIP1, SMADIP1, ZFHX1B, HSPC082
Protein Interaction Partner: CTBP1, SOX2, SMAD9, SMAD3, SMAD2, SMAD1, APP, HDAC4, CBX4, SUMO1, UBE2I, ELAVL1, UBC, MTA2, MTA1, RBBP7, RBBP4, HDAC2, HDAC1, CEBPA, COPS6, SMAD5, CTBP2,
Protein Size: 1214

Poids moléculaire: 136 kDa

ID gène: 9839

NCBI Accession: NM_014795, NP_055610

UniProt: O60315

Pathways: Tube Formation