NUP98 anticorps (N-Term)
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- Antigène Voir toutes NUP98 Anticorps
- NUP98 (Nucleoporin 98kDa (NUP98))
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Épitope
- N-Term
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Reactivité
- Humain, Souris, Rat, Chien, Cheval, Lapin, Boeuf (Vache), Cobaye, Saccharomyces cerevisiae, Poisson zèbre (Danio rerio)
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp NUP98 est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (IF)
- Séquence
- AFGTSAFGSS NNTGGLFGNS QTKPGGLFGT SSFSQPATST STGFGFGTST
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 91%, Zebrafish: 85%
- Attributs du produit
- This is a rabbit polyclonal antibody against NUP98. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the N terminal region of human NUP98
- Top Product
- Discover our top product NUP98 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 1800 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- NUP98 (Nucleoporin 98kDa (NUP98))
- Autre désignation
- NUP98 (NUP98 Produits)
- Synonymes
- anticorps CG10198, anticorps CG10201, anticorps Dmel\\CG10198, anticorps Nup 96, anticorps Nup 98, anticorps Nup-98, anticorps Nup96, anticorps Nup98, anticorps Nup98-Nup96, anticorps Nup98/96, anticorps l(3)95BCd, anticorps nup145, anticorps nup98-96, anticorps GB12688, anticorps NUP98, anticorps 4732457F17, anticorps AI849286, anticorps im:7151238, anticorps zgc:113968, anticorps zgc:63593, anticorps ADIR2, anticorps NUP196, anticorps NUP96, anticorps Nucleoporin 98-96kD, anticorps nuclear pore complex protein Nup98-Nup96, anticorps nucleoporin 98, anticorps nucleoporin 98kDa, anticorps nucleoporin 98 L homeolog, anticorps Nup98-96, anticorps LOC408335, anticorps NUP98, anticorps LOC587580, anticorps Nup98, anticorps nup98, anticorps nup98.L
- Sujet
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The nuclear pore complex (NPC) is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kD nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kD precursor protein. This cleavage results in the 98 kD nucleoporin as well as a 96 kD nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kD nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromsome translocatons in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants, however, not all variants have been fully described.
Alias Symbols: ADIR2, NUP196, NUP96
Protein Interaction Partner: UBC, SUMO2, SUMO3, CDC37, EED, CDC73, PAF1, ARFGEF2, FBXO6, NXF1, HDAC11, HDAC8, LMNA, HNRNPUL1, CSNK2A1, ECT2, NUP107, RAE1, SUMO1, NUMA1, rev, SIRT7, RAPGEF3, CTNNB1, NUP88, NUP159, NUP82, Nup98, Nup214, Nup188, tat, HDAC1, CREBBP, PTTG1, APC, NPM1, USP
Protein Size: 1800 - Poids moléculaire
- 196 kDa
- ID gène
- 4928
- NCBI Accession
- NM_016320, NP_057404
- Pathways
- Stem Cell Maintenance, Protein targeting to Nucleus, SARS-CoV-2 Protein Interactome
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