NR1I2 anticorps (C-Term)
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- Antigène Voir toutes NR1I2 Anticorps
- NR1I2 (Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2))
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Épitope
- C-Term
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Reactivité
- Humain, Souris, Rat, Porc, Cheval, Boeuf (Vache), Chien, Cobaye, Lapin
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp NR1I2 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- PQPAHRFLFL KIMAMLTELR SINAQHTQRL LRIQDIHPFA TPLMQELFGI
- Homologie
- Cow: 77%, Dog: 100%, Guinea Pig: 85%, Horse: 93%, Human: 100%, Mouse: 92%, Pig: 100%, Rabbit: 93%, Rat: 92%
- Attributs du produit
- This is a rabbit polyclonal antibody against NR1I2. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Protein A purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the C terminal region of human NR1I2
- Top Product
- Discover our top product NR1I2 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 473 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- NR1I2 (Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2))
- Autre désignation
- NR1I2 (NR1I2 Produits)
- Synonymes
- anticorps BXR, anticorps ONR1, anticorps PAR, anticorps PAR1, anticorps PAR2, anticorps PARq, anticorps PRR, anticorps PXR, anticorps SAR, anticorps SXR, anticorps PXR.1, anticorps PXR.2, anticorps PXR1, anticorps mPXR, anticorps bxr, anticorps nr1i2, anticorps onr1, anticorps xonr1, anticorps nuclear receptor subfamily 1 group I member 2, anticorps nuclear receptor subfamily 1, group I, member 2, anticorps nuclear receptor subfamily 1 group I member 2 S homeolog, anticorps NR1I2, anticorps Nr1i2, anticorps nr1i2.S, anticorps nr1i2
- Sujet
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NR1I2 belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. NR1I2 contains a zinc finger domain.NR1I2 is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. The gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. The gene product contains a zinc finger domain. Three alternatively spliced transcripts that encode different isoforms have been described, one of which encodes two products through the use of alternative translation initiation codons. Additional transcript variants derived from alternative promoter usage, alternative splicing, and/or alternative polyadenylation exist, but they have not been fully described.
Alias Symbols: BXR, PAR, PRR, PXR, SAR, SXR, ONR1, PAR1, PAR2, PARq
Protein Interaction Partner: NCOA1, RPS6KB1, UBC, RBBP7, DDB1, UBR5, DYRK2, NCOR2, SDF4, NCOA3, TFAP2C, MAPK7, NFATC4, HSP90AA1, FGR, ATP6AP1, RXRA, RBCK1, NCOA2, SUMO1, SUMO2, SUMO3, NCOA6, SRC, RXRG, RXRB, CHMP1A, NUCB2, ACTN2, PPARGC1A, EIF3I, TADA3, NCOR1, PRMT1, NR1I2, PSMC5, PO
Protein Size: 473 - Poids moléculaire
- 54 kDa
- ID gène
- 8856
- NCBI Accession
- NM_022002, NP_071285
- UniProt
- Q9UNW4
- Pathways
- Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway
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