GLS2 anticorps (Middle Region)

N° du produit ABIN2781319

Détail du produit anti-GLS2 anticorps

Antigène: GLS2 (Glutaminase 2 (Liver, Mitochondrial) (GLS2))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Porc, Chien, Poisson zèbre (Danio rerio), Cheval, Lapin, Boeuf (Vache), Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GLS2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: FVGKEPSGLR YNKLSLNEEG IPHNPMVNAG AIVVSSLIKM DCNKAEKFDF

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 79%

Attributs du produit: This is a rabbit polyclonal antibody against GLS2. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human GLS2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 327 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-GLS2 (ABIN2781319)

Hu, Lausted, Yoo, Yan, Brightman, Chen, Wang, Bu, Hood: "Quantitative liver-specific protein fingerprint in blood: a signature for hepatotoxicity." dans: Theranostics, Vol. 4, Issue 2, pp. 215-28, (2014) (PubMed).

Toriumi, Mouri, Narusawa, Aoyama, Ikawa, Lu, Nagai, Mamiya, Kim, Nabeshima: "Prenatal NMDA receptor antagonism impaired proliferation of neuronal progenitor, leading to fewer glutamatergic neurons in the prefrontal cortex." dans: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Vol. 37, Issue 6, pp. 1387-96, (2012) (PubMed).

Détails sur GLS2

Antigène: GLS2 (Glutaminase 2 (Liver, Mitochondrial) (GLS2))

Autre désignation: GLS2 (GLS2 Produits)

Synonymes: anticorps si:ch211-216k22.10, anticorps GA, anticorps GLS, anticorps LGA, anticorps hLGA, anticorps A330074B06Rik, anticorps AI195532, anticorps Lga, anticorps Ga, anticorps glutaminase 2, anticorps glutaminase 2a (liver, mitochondrial), anticorps glutaminase 2 (liver, mitochondrial), anticorps glsA2, anticorps LOAG_03311, anticorps gls2a, anticorps GLS2, anticorps Gls2

Sujet: GLS2 is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. This protein is functionally similar to the kidney glutaminase but is a little smaller in size. Originally thought to be liver-specific, this protein has been found in other tissues as well.
Alias Symbols: GA, GLS, LGA, MGC71567, hLGA
Protein Interaction Partner: SNTA1, GRHPR, TAX1BP3, PAG1, DLG2, INADL, DLG4, RGS3, DLG1, DLG3, CASK,
Protein Size: 327

Poids moléculaire: 36 kDa

ID gène: 27165

NCBI Accession: NM_013267

UniProt: Q9UI32

Pathways: Dicarboxylic Acid Transport, L'effet Warburg