Calsyntenin 1 anticorps (N-Term)
-
- Antigène Voir toutes Calsyntenin 1 (CLSTN1) Anticorps
- Calsyntenin 1 (CLSTN1)
-
Épitope
- N-Term
-
Reactivité
- Humain, Souris, Rat, Lapin, Poisson zèbre (Danio rerio), Boeuf (Vache), Cobaye, Cheval, Chien
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp Calsyntenin 1 est non-conjugé
-
Application
- Western Blotting (WB)
- Séquence
- KPWLEPTYHG IVTENDNTVL LDPPLIALDK DAPLRFAESF EVTVTKEGEI
- Homologie
- Cow: 82%, Dog: 92%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%
- Attributs du produit
- This is a rabbit polyclonal antibody against CLSTN1. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the N terminal region of human CLSTN1
- Top Product
- Discover our top product CLSTN1 Anticorps primaire
-
-
- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
-
Antigen size: 981 AA
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
- Antigène
- Calsyntenin 1 (CLSTN1)
- Autre désignation
- CLSTN1 (CLSTN1 Produits)
- Synonymes
- anticorps CALSYNTENIN-1, anticorps fm67g03, anticorps wu:fk52g02, anticorps wu:fm67g03, anticorps zgc:153744, anticorps zgc:56528, anticorps clstn1, anticorps 1810034E21Rik, anticorps Cst-1, anticorps Cstn1, anticorps ALC-ALPHA, anticorps CDHR12, anticorps CSTN1, anticorps PIK3CD, anticorps XB31alpha, anticorps alcalpha1, anticorps alcalpha2, anticorps calsyntenin 1, anticorps calsyntenin 3, anticorps beta-catenin-interacting protein 1, anticorps calsyntenin-1, anticorps CLSTN1, anticorps clstn1, anticorps clstn3, anticorps LOC100356725, anticorps LOC100435584, anticorps Clstn1, anticorps LOC479600
- Sujet
-
CLSTN1 induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, CLSTN1 stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment,CLSTN1 abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding.CLSTN1 may modulate calcium-mediated postsynaptic signals.
Alias Symbols: CSTN1, FLJ32258, KIAA0911, PIK3CD, XB31alpha, alcalpha1, alcalpha2, CDHR12, ALC-ALPHA
Protein Interaction Partner: MDM2, BAHCC1, SETDB1, SLK, TRIP12, MCM3AP, UBC, KLC2, CLSTN1, TOPBP1, APBA2, APBB1, KIF2A, KLC1, PRNP, COL17A1, PSEN1, APP,
Protein Size: 981 - Poids moléculaire
- 110 kDa
- ID gène
- 22883
- NCBI Accession
- NM_001009566, NP_001009566
- UniProt
- O94985
-