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CPT1A anticorps (Middle Region)

CPT1A Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Mouton, Poisson zèbre (Danio rerio) WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2782010
  • Antigène Voir toutes CPT1A Anticorps
    CPT1A (Carnitine Palmitoyltransferase 1A (Liver) (CPT1A))
    Épitope
    • 8
    • 6
    • 6
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivité
    • 41
    • 18
    • 14
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Mouton, Poisson zèbre (Danio rerio)
    Hôte
    • 54
    • 4
    • 2
    Lapin
    Clonalité
    • 55
    • 5
    Polyclonal
    Conjugué
    • 31
    • 11
    • 9
    • 4
    • 3
    • 2
    Cet anticorp CPT1A est non-conjugé
    Application
    • 54
    • 33
    • 21
    • 7
    • 6
    • 6
    • 5
    • 5
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Séquence
    LSTSQTPQQQ VELFDLENNP EYVSSGGGFG PVADDGYGVS YILVGENLIN
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%
    Attributs du produit
    This is a rabbit polyclonal antibody against CPT1A. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the middle region of human CPT1A
    Top Product
    Discover our top product CPT1A Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 756 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Piemontese, Cerchia, Laghezza, Ziccardi, Sblano, Tortorella, Iacobazzi, Infantino, Convertini, Dal Piaz, Lupo, Colantuoni, Lavecchia, Loiodice: "New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity." dans: European journal of medicinal chemistry, Vol. 127, pp. 379-397, (2017) (PubMed).

    Convertini, Menga, Andria, Scala, Santarsiero, Castiglione Morelli, Iacobazzi, Infantino: "The contribution of the citrate pathway to oxidative stress in Down syndrome." dans: Immunology, Vol. 149, Issue 4, pp. 423-431, (2016) (PubMed).

    Laghezza, Pochetti, Lavecchia, Fracchiolla, Faliti, Piemontese, Di Giovanni, Iacobazzi, Infantino, Montanari, Capelli, Tortorella, Loiodice: "New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor ?/? dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression." dans: Journal of medicinal chemistry, Vol. 56, Issue 1, pp. 60-72, (2013) (PubMed).

  • Antigène
    CPT1A (Carnitine Palmitoyltransferase 1A (Liver) (CPT1A))
    Autre désignation
    CPT1A (CPT1A Produits)
    Sujet
    The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation.The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
    Alias Symbols: CPT1, CPT1-L, L-CPT1
    Protein Interaction Partner: UBC, SUMO2, LGR4, RNF2, FBXO6, PARK2, LYN, CLN3, HDAC11, KBTBD7, NPDC1, HSPA5, NR4A1, CYBA, CLIC1, SNRNP200, ERLIN1, TOMM40, EIF3C, PCBP1, NDUFV1, NDUFS1, NDUFA2, LPP, CPS1, ATP6V1C1, RHOA, PCK1, BCL2,
    Protein Size: 756
    Poids moléculaire
    86 kDa
    ID gène
    1374
    NCBI Accession
    NM_001031847, NP_001027017
    UniProt
    P50416
    Pathways
    AMPK Signaling, Regulation of Lipid Metabolism by PPARalpha, Feeding Behaviour, Monocarboxylic Acid Catabolic Process
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