PTPRR anticorps (C-Term)
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- Antigène Voir toutes PTPRR Anticorps
- PTPRR (Protein tyrosine Phosphatase, Receptor Type, R (PTPRR))
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Épitope
- C-Term
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Reactivité
- Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Lapin, Cheval
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp PTPRR est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- NYTIRNLVLK QGSHTQHVKH YWYTSWPDHK TPDSAQPLLQ LMLDVEEDRL
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against PTPRR. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the C terminal region of human PTPRR
- Top Product
- Discover our top product PTPRR Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 412 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- PTPRR (Protein tyrosine Phosphatase, Receptor Type, R (PTPRR))
- Autre désignation
- PTPRR (PTPRR Produits)
- Synonymes
- anticorps EC-PTP, anticorps PCPTP1, anticorps PTP-SL, anticorps PTPBR7, anticorps PTPRQ, anticorps Pcptp1, anticorps ec-ptp, anticorps pcptp1, anticorps ptp-sl, anticorps ptpbr7, anticorps PTPRR, anticorps Gmcp1, anticorps RPTPRR, anticorps mPTP213, anticorps protein tyrosine phosphatase, receptor type R, anticorps protein tyrosine phosphatase, receptor type, R, anticorps protein tyrosine phosphatase, receptor type R L homeolog, anticorps protein tyrosine phosphatase, receptor type, r, anticorps receptor-type tyrosine-protein phosphatase R, anticorps PTPRR, anticorps Ptprr, anticorps ptprr.L, anticorps ptprr, anticorps LOC100715069
- Sujet
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PTPRR is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domains, and thus represents a receptor-type PTP.The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domains, and thus represents a receptor-type PTP. The similar gene predominately expressed in mouse brain was found to associate with, and thus regulate the activity and cellular localization of MAP kinases. The rat counterpart of this gene was reported to be regulated by the nerve growth factor, which suggested the function of this gene in neuronal growth and differentiation. Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, and an RNA component, encoded by this gene, that serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Mutations in this gene cause autosomal dominant dyskeratosis congenita, and may also be associated with some cases of aplastic anemia.
Alias Symbols: DKFZp781C1038, EC-PTP, FLJ34328, MGC131968, MGC148170, PCPTP1, PTP-SL, PTPBR7, PTPRQ
Protein Interaction Partner: MAPK3, MAPK1, MAPK7, PRKACA,
Protein Size: 412 - Poids moléculaire
- 46 kDa
- ID gène
- 5801
- NCBI Accession
- NM_130846, NP_570897
- UniProt
- Q7Z2V8
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