FEN1 anticorps (C-Term)
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- Antigène Voir toutes FEN1 Anticorps
- FEN1 (Flap Structure-Specific Endonuclease 1 (FEN1))
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Épitope
- C-Term
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Reactivité
- Humain, Souris, Rat, Mouton, Boeuf (Vache), Cheval, Cobaye, Lapin, Chien, Poisson zèbre (Danio rerio)
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp FEN1 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- PNEEELIKFM CGEKQFSEER IRSGVKRLSK SRQGSTQGRL DDFFKVTGSL
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 93%
- Attributs du produit
- This is a rabbit polyclonal antibody against FEN1. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Protein A purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the C terminal region of human FEN1
- Top Product
- Discover our top product FEN1 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 380 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- FEN1 (Flap Structure-Specific Endonuclease 1 (FEN1))
- Autre désignation
- FEN1 (FEN1 Produits)
- Synonymes
- anticorps FEN-1, anticorps FEN1, anticorps AW538437, anticorps MF1, anticorps RAD2, anticorps cb879, anticorps fen-1, anticorps fen1, anticorps mf1, anticorps rad2, anticorps xFEN1a, anticorps flap structure-specific endonuclease 1, anticorps flap endonuclease 1-like, anticorps Flap endonuclease-1, anticorps 5'-3' exonuclease family protein, anticorps flap structure specific endonuclease 1, anticorps flap structure-specific endonuclease 1 L homeolog, anticorps nuclease, Rad2 family, anticorps FEN1, anticorps LOC100808044, anticorps Bm1_49605, anticorps AT5G26680, anticorps Fen1, anticorps fen1, anticorps fen1.L
- Sujet
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FEN1 removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.
Alias Symbols: FEN-1, MF1, RAD2
Protein Interaction Partner: SUMO2, SUMO3, PCNA, UBC, SHFM1, ELAC2, TNPO3, PPP2R5D, HARS, LPP, PFDN1, WRN, AICDA, RAD1, FN1, PAXIP1, APP, VRK1, RAP1A, cdt1, TERF1, RAD21, GSK3B, ENDOG, DDX11, NCAPG, EP300, BLM, EEF1G, ARHGDIA, HNRNPA1, CDK2, CDK1, APEX1, RAD9A, HUS1, CCNA2,
Protein Size: 380 - Poids moléculaire
- 42 kDa
- ID gène
- 2237
- NCBI Accession
- NM_004111, NP_004102
- UniProt
- P39748
- Pathways
- Telomere Maintenance, Réparation de l'ADN, DNA Replication, Synthesis of DNA
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