MELK anticorps (N-Term)
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- Antigène Voir toutes MELK Anticorps
- MELK (Maternal Embryonic Leucine Zipper Kinase (MELK))
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Épitope
- N-Term
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Reactivité
- Humain, Souris, Rat, Boeuf (Vache), Cheval, Chien, Lapin, Cobaye, Porc
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp MELK est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- GFAKVKLACH VLTGEMVAIK IMDKNALGSD LPRVKTEIDA LKSLRHQHIC
- Homologie
- Cow: 86%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 86%, Pig: 93%, Rabbit: 86%, Rat: 86%
- Attributs du produit
- This is a rabbit polyclonal antibody against Melk. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the N-terminal region of Mouse Melk
- Top Product
- Discover our top product MELK Anticorps primaire
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeat freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- MELK (Maternal Embryonic Leucine Zipper Kinase (MELK))
- Autre désignation
- Melk (MELK Produits)
- Synonymes
- anticorps MELK, anticorps xmelk, anticorps Melk, anticorps HPK38, anticorps AI327312, anticorps MPK38, anticorps mKIAA0175, anticorps fb71b01, anticorps fe01f04, anticorps wu:fb71b01, anticorps wu:fe01f04, anticorps maternal embryonic leucine zipper kinase, anticorps maternal embryonic leucine zipper kinase L homeolog, anticorps MELK, anticorps melk, anticorps cgd5_2270, anticorps Melk, anticorps melk.L
- Sujet
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Melk is a Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity, phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Melk Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. It Plays a key role in cell proliferation. It is required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14. It's also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus and may also play a role in primitive hematopoiesis.
Alias Symbols: AI327312, MPK38, mKIAA0175
Protein Interaction Partner: Txn1, ZNF622, UBC, TXN, TP53, MAP3K5, MDM2, SMAD7, SMAD3,
Protein Size: 643 - Poids moléculaire
- 70 kDa
- ID gène
- 17279
- NCBI Accession
- NM_010790, NP_034920
- UniProt
- Q61846
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