COX15 anticorps (N-Term)

N° du produit ABIN2782632

Détail du produit anti-COX15 anticorps

Antigène: COX15 (Cytochrome C Oxidase Assembly Homolog 15 (COX15))

Épitope: N-Term

Reactivité: Humain, Rat, Souris, Lapin, Chien, Poisson zèbre (Danio rerio), Boeuf (Vache), Saccharomyces cerevisiae, Cobaye, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp COX15 est non-conjugé

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Séquence: DWHLIKEMKP PTSQEEWEAE FQRYQQFPEF KILNHDMTLT EFKFIWYMEY

Homologie: Cow: 93%, Dog: 86%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 86%, Rat: 93%, Yeast: 82%, Zebrafish: 79%

Attributs du produit: This is a rabbit polyclonal antibody against COX15. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human COX15

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 388 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-COX15 (ABIN2782632)

Swenson, Cannon, Harris, Taylor, Fox, Khalimonchuk: "Analysis of Oligomerization Properties of Heme a Synthase Provides Insights into Its Function in Eukaryotes." dans: The Journal of biological chemistry, Vol. 291, Issue 19, pp. 10411-25, (2016) (PubMed).

Détails sur COX15

Antigène: COX15 (Cytochrome C Oxidase Assembly Homolog 15 (COX15))

Autre désignation: COX15 (COX15 Produits)

Sujet: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be essential for the biogenesis of COX formation and may function in the hydroxylation of heme O, according to the yeast mutant studies. This protein is predicted to contain 5 transmembrane domains localized in the mitochondrial inner membrane.Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be essential for the biogenesis of COX formation and may function in the hydroxylation of heme O, according to the yeast mutant studies. This protein is predicted to contain 5 transmembrane domains localized in the mitochondrial inner membrane. Alternative splicing of this gene generates several transcript variants diverging in the 3' region including alternate poly A sites. In total, 2 different isoforms are encoded by these variants.
Alias Symbols: -
Protein Interaction Partner: UBC, CLN3, MRPS14, NDUFA12, TOMM7, MRPL15, LAMTOR3, SURF1, NDUFS8, NDUFS6, NDUFS4, NDUFA9, CYC1,
Protein Size: 388

Poids moléculaire: 44 kDa

ID gène: 1355

NCBI Accession: NM_004376, NP_004367